Introduction
Methods
Study population
Clinical data
Echocardiographic analyses
Outcomes and analyses
Statistical analyses
Results
Classical LBBB contraction pattern
All | No Classical | Classical | ||
---|---|---|---|---|
n = 283 | n = 87 | n = 196 | p-value | |
Age, years | 66 ± 11 | 67 ± 9 | 65 ± 12 | 0.13 |
Women | 113 (40%) | 20 (23%) | 93 (47%) | < 0.001 |
Days from ECG to CRTa | 6 (2–25) | 7 (3–24) | 6 (1–24) | 0.89 |
Ischemic heart disease | 136 (48%) | 55 (63%) | 81 (41%) | < 0.001 |
NYHA class III/IV | 230 (81%) | 74 (85%) | 156 (80%) | 0.32 |
QRS duration, ms | 157 ± 21 | 146 ± 17 | 162 ± 21 | < 0.001 |
QRS duration < 150 ms | 110 (39%) | 53 (61%) | 57 (29%) | < 0.001 |
Strict LBBB | 226 (80%) | 55 (63%) | 171 (87%) | < 0.001 |
1st degree AV block | 51 (18%) | 16 (18%) | 35 (18%) | 0.99 |
Atrial fibrillation/flutter | 82 (29%) | 30 (34%) | 52 (27%) | 0.20 |
Hypertension | 195 (69%) | 67 (77%) | 128 (65%) | 0.05 |
Diabetes | 90 (32%) | 40 (46%) | 50 (26%) | < 0.001 |
Creatinine, mg/dL+ | 1.2 (1.0–1.5) | 1.3 (1.0–1.6) | 1.1 (0.9–1.5) | 0.01 |
ACE/ARB | 230 (81%) | 68 (78%) | 162 (83%) | 0.32 |
Betablocker | 257 (91%) | 79 (91%) | 178 (91%) | 0.82 |
All | No Classical | Classical | ||
---|---|---|---|---|
n = 283 | n = 87 | n = 196 | p-value | |
Days from echo to CRTa | 30 (5–78) | 22 (5–78) | 34 (5–75) | 0.89 |
LVEDV, mL | 226 ± 83 | 214 ± 82 | 231 ± 83 | 0.11 |
LVESV, mL | 180 ± 75 | 164 ± 67 | 187 ± 78 | 0.02 |
LVEF, % | 21 ± 7 | 23 ± 7 | 20 ± 7 | < 0.001 |
End-systolic GLS, % | −7.0 ± 2.9 | −7.9 ± 2.6 | −6.7 ± 3.0 | 0.001 |
Frame rate ≤ 30 frames/s | 159 (56%) | 48 (55%) | 111 (57%) | 0.90 |
< 25 frames per cardiac cycle | 88 (31%) | 18 (21%) | 70 (36%) | 0.01 |
Sinus rhythm on baseline echo | 242 (86%) | 75 (86%) | 167 (85%) | 0.99 |
Heart rate on baseline echo, min−1 | 77 ± 16 | 74 ± 14 | 79 ± 17 | 0.02 |
Primary outcome
Echocardiographic outcomes
No Classical | Classical | ||
---|---|---|---|
n = 38 | n = 85 | p-value | |
Relative ΔLV end-systolic volume, % | −7 ± 27 | −26 ± 25 | < 0.001 |
vLV end-systolic volume ≤ − 15% | 13 (34%) | 64 (75%) | < 0.001 |
Relative ΔLV end-diastolic volume, % | 0 ± 24 | −16 ± 22 | < 0.001 |
Absolute ΔLV ejection fraction, %-points | 7 ± 11 | 11 ± 10 | 0.03 |
Absolute ΔLV end-systolic GLS, %-points | −1.8 ± 4.1 | −3.6 ± 3.8 | 0.02 |