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07.12.2023 | Original Communication

The brief repeatable battery of neuropsychological tests (BRB-N) version a: update of Italian normative data from the Italian Neuroimaging Network Initiative (INNI)

verfasst von: Nicolò Tedone, Carmen Vizzino, Alessandro Meani, Antonio Gallo, Manuela Altieri, Alessandro D’Ambrosio, Patrizia Pantano, Claudia Piervincenzi, Silvia Tommasin, Nicola De Stefano, Rosa Cortese, Maria L. Stromillo, Maria A. Rocca, Massimo Filippi, INNI network

Erschienen in: Journal of Neurology | Ausgabe 4/2024

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Abstract

Background

Cognitive impairment is a common clinical manifestation in people with multiple sclerosis (PwMS) and significantly impacts patients' quality life. Cognitive assessment is crucial for treatment decisions and understanding disease progression. Several neuropsychological batteries are used in MS, including the Brief Repeatable Battery of Neuropsychological Tests (BRB-N), Minimal Assessment of Cognitive Function in MS (MACFIMS), and Brief International Cognitive Assessment for MS (BICAMS). However, normative data for BRB-N version A in Italy are outdated.

Objectives

To revise and update normative data for the BRB-N version A in the Italian population.

Methods

From the Italian Neuroimaging Network Initiative (INNI) database, we retrospectively selected 342 healthy subjects (172 males and 170 females) evaluated at four Italian INNI-affiliated sites (Milan, Siena, Rome, Naples). The subjects underwent neuropsychological assessment using the BRB-N version A. Regression-based method relying on scaled scores was used to calculate demographic correction procedures.

Results

No significant differences were found in age, education, and sex distribution among the four sites (p ≥ 0.055). Regression analysis provided normative data to calculate demographically adjusted z-scores for each BRB-N version A test.

Discussion

This study provides updated normative data for the BRB-N version A in the Italian population. The use of a regression-based method and scaled scores ensures consistency with other neuropsychological batteries commonly used in Italy, namely MACFIMS and BICAMS. The availability of updated normative data increases reliability of neuropsychological assessment of cognitive function in Italian PwMS and other clinical populations using BRB-N version A, providing valuable insights for both clinical and research applications.

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Titel: The brief repeatable battery of neuropsychological tests (BRB-N) version a: update of Italian normative data from the Italian Neuroimaging Network Initiative (INNI)
verfasst von: Nicolò Tedone
Carmen Vizzino
Alessandro Meani
Antonio Gallo
Manuela Altieri
Alessandro D’Ambrosio
Patrizia Pantano
Claudia Piervincenzi
Silvia Tommasin
Nicola De Stefano
Rosa Cortese
Maria L. Stromillo
Maria A. Rocca
Massimo Filippi
INNI network
Publikationsdatum: 07.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 4/2024
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-12108-z

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Objectives

Methods

Results

Discussion

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