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Head and Neck Pathology

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04.04.2023 | Case Reports

The Challenge of “Monomorphic” Mucoepidermoid Carcinoma—Report of a Rare Case with Pure Spindle-Clear Cell Morphology

verfasst von: Xinyi Qu, Edwin Jun Chen Chew, Sathiyamoorthy Selvarajan, Bingcheng Wu, Abbas Agaimy, Fredrik Petersson

Erschienen in: Head and Neck Pathology | Ausgabe 3/2023

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Abstract

Background

Mucoepidermoid carcinoma is a malignant salivary gland tumor which, in most cases, is composed of variable proportions of mucous, epidermoid, and intermediate cells.

Methods

We report a case of parapharyngeal mucoepidermoid carcinoma with highly unusual (“monomorphic”) light microscopic features as well as atypical immunohistochemical properties. Molecular analysis was performed using the TruSight RNA fusion panel.

Results

The tumor featured heretofore undescribed histopathological features: sheets and nests composed of monomorphic neoplastic (plump spindle to epithelioid) cells with no mucous, intermediate, glandular/columnar, or any other cell type identified. The neoplastic cells displayed variable clear cell change and only expressed cytokeratin 7. Despite this non-classical morphology, the presence of the classical CRTC1::MAML2 fusion was demonstrated.

Conclusions

Mucoepidermoid carcinoma featuring a uniform (“monomorphic”) population of neoplastic cells is a novel observation. A confident diagnosis of mucoepidermoid carcinoma can be made upon detection of the CRTC1/3::MAML2 fusion. Our case increases the spectrum of histopathological appearances that mucoepidermoid carcinoma may display.

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Titel: The Challenge of “Monomorphic” Mucoepidermoid Carcinoma—Report of a Rare Case with Pure Spindle-Clear Cell Morphology
verfasst von: Xinyi Qu
Edwin Jun Chen Chew
Sathiyamoorthy Selvarajan
Bingcheng Wu
Abbas Agaimy
Fredrik Petersson
Publikationsdatum: 04.04.2023
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 3/2023
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-023-01547-9

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The Challenge of “Monomorphic” Mucoepidermoid Carcinoma—Report of a Rare Case with Pure Spindle-Clear Cell Morphology

Abstract

Background

Methods

Results

Conclusions

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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