Skip to main content

15.03.2024

The Diagnostic Approach of Benign Esophageal Tumors: A Narrative Review

verfasst von: Alex R. Jones, MD, Preksha Vankawala, MD, Tarek Sawas, MD, MPH

Erschienen in: Current Treatment Options in Gastroenterology

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Benign esophageal tumors (BETs) pose diagnostic challenges due to overlapping clinical and imaging features, necessitating advancements in diagnostic techniques. Distinguishing between tumors with and without malignant potential is essential to guide management. We aim to review the diagnostic approach to BETs with an emphasis on recent advances.

Recent Findings

EUS-guided tissue acquisition is the current gold standard, particularly in subepithelial lesions (SELs). EUS with fine-needle biopsy (FNB) is considered superior to fine-needle aspiration (FNA), unless rapid on-site evaluation (ROSE) is available. The influence of needle size and suction technique has limited impact on the tissue sample quality. Mucosal-incision–assisted biopsy aims to improve diagnostic yield for smaller SELs and improve accessibility of diagnostic techniques. Recent studies assessing integration of artificial intelligence have shown promise in improving diagnostic accuracy.

Summary

Retrospective data shows promise for technologies intended to improve both non-invasive and invasive modalities for the diagnosis of BETs. Future research should aim to prospectively explore these strategies and include lesions throughout the gastrointestinal tract.
Literatur
1.
Zurück zum Zitat Ha C, Regan J, Cetindag IB, Ali A, Mellinger JD. Benign esophageal tumors. Surg Clin North Am. 2015;95(3):491–514.PubMedCrossRef Ha C, Regan J, Cetindag IB, Ali A, Mellinger JD. Benign esophageal tumors. Surg Clin North Am. 2015;95(3):491–514.PubMedCrossRef
2.
Zurück zum Zitat Rice TW. Benign esophageal tumors: Esophagoscopy and endoscopic esophageal ultrasound. Semin Thorac Cardiovasc Surg. 2003;15(1):20–6.PubMedCrossRef Rice TW. Benign esophageal tumors: Esophagoscopy and endoscopic esophageal ultrasound. Semin Thorac Cardiovasc Surg. 2003;15(1):20–6.PubMedCrossRef
3.
Zurück zum Zitat Menon L, Buscaglia JM. Endoscopic approach to subepithelial lesions. Ther Adv Gastroenterol. 2014;7(3):123–30.CrossRef Menon L, Buscaglia JM. Endoscopic approach to subepithelial lesions. Ther Adv Gastroenterol. 2014;7(3):123–30.CrossRef
4.
Zurück zum Zitat •• Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, et al. ACG clinical guideline: diagnosis and management of gastrointestinal subepithelial lesions. Am J Gastroenterol. 2023;118(1):46–58. American College of Gastroenterology clinical guidelines for the diagnosis and management of gastrointestinal SELs with review of pertinent literature corresponding to recommendations.PubMedCrossRef •• Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, et al. ACG clinical guideline: diagnosis and management of gastrointestinal subepithelial lesions. Am J Gastroenterol. 2023;118(1):46–58. American College of Gastroenterology clinical guidelines for the diagnosis and management of gastrointestinal SELs with review of pertinent literature corresponding to recommendations.PubMedCrossRef
5.
Zurück zum Zitat Sharzehi K, Sethi A, Savides T. AGA clinical practice update on management of subepithelial lesions encountered during routine endoscopy: expert review. Clin Gastroenterol Hepatol. 2022;20(11):2435-2443.e4.PubMedCrossRef Sharzehi K, Sethi A, Savides T. AGA clinical practice update on management of subepithelial lesions encountered during routine endoscopy: expert review. Clin Gastroenterol Hepatol. 2022;20(11):2435-2443.e4.PubMedCrossRef
6.
Zurück zum Zitat Polkowski M, Larghi A, Weynand B, Boustière C, Giovannini M, Pujol B, et al. Learning, techniques, and complications of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) technical guideline. Endoscopy. 2012;44(02):190–206.PubMedCrossRef Polkowski M, Larghi A, Weynand B, Boustière C, Giovannini M, Pujol B, et al. Learning, techniques, and complications of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) technical guideline. Endoscopy. 2012;44(02):190–206.PubMedCrossRef
7.
Zurück zum Zitat Faulx AL, Kothari S, Acosta RD, Agrawal D, Bruining DH, Chandrasekhara V, et al. The role of endoscopy in subepithelial lesions of the GI tract. Gastrointest Endosc. 2017;85(6):1117–32.PubMedCrossRef Faulx AL, Kothari S, Acosta RD, Agrawal D, Bruining DH, Chandrasekhara V, et al. The role of endoscopy in subepithelial lesions of the GI tract. Gastrointest Endosc. 2017;85(6):1117–32.PubMedCrossRef
8.
Zurück zum Zitat Hwang JH, Saunders MD, Rulyak SJ, Shaw S, Nietsch H, Kimmey MB. A prospective study comparing endoscopy and EUS in the evaluation of GI subepithelial masses. Gastrointest Endosc. 2005;62(2):202–8.PubMedCrossRef Hwang JH, Saunders MD, Rulyak SJ, Shaw S, Nietsch H, Kimmey MB. A prospective study comparing endoscopy and EUS in the evaluation of GI subepithelial masses. Gastrointest Endosc. 2005;62(2):202–8.PubMedCrossRef
9.
Zurück zum Zitat Alkhatib AA, Faigel DO. Endoscopic ultrasonography-guided diagnosis of subepithelial tumors. Gastrointest Endosc Clin N Am. 2012;22(2):187–205.PubMedCrossRef Alkhatib AA, Faigel DO. Endoscopic ultrasonography-guided diagnosis of subepithelial tumors. Gastrointest Endosc Clin N Am. 2012;22(2):187–205.PubMedCrossRef
10.
Zurück zum Zitat Khan S, Zhang R, Fang W, Wang T, Li S, Wang D, et al. Reliability of endoscopic ultrasound using miniprobes and grayscale histogram analysis in diagnosing upper gastrointestinal subepithelial lesions. Gastroenterol Res Pract. 2020;2020:1–9.CrossRef Khan S, Zhang R, Fang W, Wang T, Li S, Wang D, et al. Reliability of endoscopic ultrasound using miniprobes and grayscale histogram analysis in diagnosing upper gastrointestinal subepithelial lesions. Gastroenterol Res Pract. 2020;2020:1–9.CrossRef
11.
Zurück zum Zitat Yamashita Y, Yoshikawa T, Kawaji Y, Tamura T, Hatamaru K, Itonaga M, et al. Novel endoscopic ultrasonography imaging technique for visualizing microcirculation without contrast enhancement in subepithelial lesions: prospective study. Dig Endosc. 2021;33:955–61.PubMed Yamashita Y, Yoshikawa T, Kawaji Y, Tamura T, Hatamaru K, Itonaga M, et al. Novel endoscopic ultrasonography imaging technique for visualizing microcirculation without contrast enhancement in subepithelial lesions: prospective study. Dig Endosc. 2021;33:955–61.PubMed
12.
Zurück zum Zitat • Yamashita Y, Ashida R, Yamazaki H, Kawaji Y, Shimokawa T, Tamura T, et al. Comparison of 22G fork-tip and Franseen needles and usefulness of contrast-enhanced endoscopic ultrasound for diagnosis of upper gastrointestinal subepithelial lesions. Diagnostics. 2022;12(12):3122. Retrospective observational study assessing the utility of contrast-enhanced harmonic EUS for evaluation of gastrointestinal SELs. Results indicate the contrast-enhanced EUS could differentiate GIST and non-GIST and could be particularly useful for lesions <2 cm.PubMedPubMedCentralCrossRef • Yamashita Y, Ashida R, Yamazaki H, Kawaji Y, Shimokawa T, Tamura T, et al. Comparison of 22G fork-tip and Franseen needles and usefulness of contrast-enhanced endoscopic ultrasound for diagnosis of upper gastrointestinal subepithelial lesions. Diagnostics. 2022;12(12):3122. Retrospective observational study assessing the utility of contrast-enhanced harmonic EUS for evaluation of gastrointestinal SELs. Results indicate the contrast-enhanced EUS could differentiate GIST and non-GIST and could be particularly useful for lesions <2 cm.PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat • Liu XY, Song W, Mao T, Zhang Q, Zhang C, Li XY. Application of artificial intelligence in the diagnosis of subepithelial lesions using endoscopic ultrasonography: a systematic review and meta-analysis. Front Oncol. 2022;12:915481. Systematic review and meta-analysis including eight studies demonstrating excellent diagnostic performance of artificial intelligence interpretation of EUS for evaluation of gastrointestinal SELs.PubMedPubMedCentralCrossRef • Liu XY, Song W, Mao T, Zhang Q, Zhang C, Li XY. Application of artificial intelligence in the diagnosis of subepithelial lesions using endoscopic ultrasonography: a systematic review and meta-analysis. Front Oncol. 2022;12:915481. Systematic review and meta-analysis including eight studies demonstrating excellent diagnostic performance of artificial intelligence interpretation of EUS for evaluation of gastrointestinal SELs.PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Ye XH, Zhao LL, Wang L. Diagnostic accuracy of endoscopic ultrasound with artificial intelligence for gastrointestinal stromal tumors: a meta-analysis. J Dig Dis. 2022;23(5–6):253–61.PubMedCrossRef Ye XH, Zhao LL, Wang L. Diagnostic accuracy of endoscopic ultrasound with artificial intelligence for gastrointestinal stromal tumors: a meta-analysis. J Dig Dis. 2022;23(5–6):253–61.PubMedCrossRef
15.
Zurück zum Zitat Minoda Y, Ihara E, Fujimori N, Nagatomo S, Esaki M, Hata Y, et al. Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. Sci Rep. 2022;12(1):16640.PubMedPubMedCentralCrossRef Minoda Y, Ihara E, Fujimori N, Nagatomo S, Esaki M, Hata Y, et al. Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. Sci Rep. 2022;12(1):16640.PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat • Khalaf K, Terrin M, Jovani M, Rizkala T, Spadaccini M, Pawlak KM, et al. A comprehensive guide to artificial intelligence in endoscopic ultrasound. J Clin Med. 2023;12(11):3757.Review article highlighting the clinical utility of using AI models for interpretation of EUS images for assessment of gastrointestinal SELs.PubMedPubMedCentralCrossRef • Khalaf K, Terrin M, Jovani M, Rizkala T, Spadaccini M, Pawlak KM, et al. A comprehensive guide to artificial intelligence in endoscopic ultrasound. J Clin Med. 2023;12(11):3757.Review article highlighting the clinical utility of using AI models for interpretation of EUS images for assessment of gastrointestinal SELs.PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Koutsoumpas A, Perera R, Melton A, Kuker J, Ghosh T, Braden B. Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours. World J Clin Cases. 2021;9(21):5822–9.PubMedPubMedCentralCrossRef Koutsoumpas A, Perera R, Melton A, Kuker J, Ghosh T, Braden B. Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours. World J Clin Cases. 2021;9(21):5822–9.PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Buscaglia JM, Nagula S, Jayaraman V, Robbins DH, Vadada D, Gross SA, et al. Diagnostic yield and safety of jumbo biopsy forceps in patients with subepithelial lesions of the upper and lower GI tract. Gastrointest Endosc. 2012;75(6):1147–52.PubMedCrossRef Buscaglia JM, Nagula S, Jayaraman V, Robbins DH, Vadada D, Gross SA, et al. Diagnostic yield and safety of jumbo biopsy forceps in patients with subepithelial lesions of the upper and lower GI tract. Gastrointest Endosc. 2012;75(6):1147–52.PubMedCrossRef
19.
Zurück zum Zitat • Collins K, Yocum BP, Mesa H, Cramer H, Saeed O. Comparison of endoscopic ultrasound-guided fine needle aspiration cytology versus endoscopic biopsy for the diagnosis of subepithelial lesions of the upper and lower gastrointestinal tract: a 10-year retrospective single institution analysis. Diagn Cytopathol. 2023;51(7):434–40. Retrospective study with 10 years of data indicating that EUS-FNA is superior to standard forceps biopsy for diagnosis of gastrointestinal subepithelial lesions.PubMedCrossRef • Collins K, Yocum BP, Mesa H, Cramer H, Saeed O. Comparison of endoscopic ultrasound-guided fine needle aspiration cytology versus endoscopic biopsy for the diagnosis of subepithelial lesions of the upper and lower gastrointestinal tract: a 10-year retrospective single institution analysis. Diagn Cytopathol. 2023;51(7):434–40. Retrospective study with 10 years of data indicating that EUS-FNA is superior to standard forceps biopsy for diagnosis of gastrointestinal subepithelial lesions.PubMedCrossRef
20.
Zurück zum Zitat Attila T, Aydin Ö. Lesion size determines diagnostic yield of EUS-FNA with onsite cytopathologic evaluation for upper gastrointestinal subepithelial lesions. Turk J Gastroenterol. 2018;29(4):436–41.PubMedPubMedCentralCrossRef Attila T, Aydin Ö. Lesion size determines diagnostic yield of EUS-FNA with onsite cytopathologic evaluation for upper gastrointestinal subepithelial lesions. Turk J Gastroenterol. 2018;29(4):436–41.PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat •• Facciorusso A, Sunny SP, Del Prete V, Antonino M, Muscatiello N. Comparison between fine-needle biopsy and fine-needle aspiration for EUS-guided sampling of subepithelial lesions: a meta-analysis. Gastrointest Endosc. 2020;91(1):14-22.e2. Meta-analysis including 10 studies comparing EUS-FNA and EUS-FNB. Demonstrated overall superiority of EUS-FNB to EUS-FNA, but non-inferiority of EUS-FNA when ROSE was available.PubMedCrossRef •• Facciorusso A, Sunny SP, Del Prete V, Antonino M, Muscatiello N. Comparison between fine-needle biopsy and fine-needle aspiration for EUS-guided sampling of subepithelial lesions: a meta-analysis. Gastrointest Endosc. 2020;91(1):14-22.e2. Meta-analysis including 10 studies comparing EUS-FNA and EUS-FNB. Demonstrated overall superiority of EUS-FNB to EUS-FNA, but non-inferiority of EUS-FNA when ROSE was available.PubMedCrossRef
22.
Zurück zum Zitat Takasumi M, Hikichi T, Hashimoto M, Nakamura J, Kato T, Kikuchi H, et al. A pilot randomized crossover trial of wet suction and conventional techniques of endoscopic ultrasound-guided fine-needle aspiration for upper gastrointestinal subepithelial lesions. Pilone V, editor. Gastroenterol Res Pract. 2021;4913107. Takasumi M, Hikichi T, Hashimoto M, Nakamura J, Kato T, Kikuchi H, et al. A pilot randomized crossover trial of wet suction and conventional techniques of endoscopic ultrasound-guided fine-needle aspiration for upper gastrointestinal subepithelial lesions. Pilone V, editor. Gastroenterol Res Pract. 2021;4913107.
23.
Zurück zum Zitat Lee JS, Cho CM, Kwon YH, Seo AN, Bae HI, Han MH. Comparison of diagnostic performances of slow-pull suction and standard suction in endoscopic ultrasound-guided fine needle biopsy for gastrointestinal subepithelial tumors. Clin Endosc. 2022;55(5):637–44.PubMedPubMedCentralCrossRef Lee JS, Cho CM, Kwon YH, Seo AN, Bae HI, Han MH. Comparison of diagnostic performances of slow-pull suction and standard suction in endoscopic ultrasound-guided fine needle biopsy for gastrointestinal subepithelial tumors. Clin Endosc. 2022;55(5):637–44.PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Moisini I, Amin K, Mallery S, Stewart J, Mettler T. Efficacy of endoscopic-guided fine-needle aspiration in the diagnosis of gastrointestinal spindle cell tumors. Diagn Cytopathol. 2018;46(8):663–9.PubMedCrossRef Moisini I, Amin K, Mallery S, Stewart J, Mettler T. Efficacy of endoscopic-guided fine-needle aspiration in the diagnosis of gastrointestinal spindle cell tumors. Diagn Cytopathol. 2018;46(8):663–9.PubMedCrossRef
25.
Zurück zum Zitat Lee CK, Chung IK, Lee SH, Lee SH, Lee TH, Park SH, et al. Endoscopic partial resection with the unroofing technique for reliable tissue diagnosis of upper GI subepithelial tumors originating from the muscularis propria on EUS (with video). Gastrointest Endosc. 2010;71(1):188–94.PubMedCrossRef Lee CK, Chung IK, Lee SH, Lee SH, Lee TH, Park SH, et al. Endoscopic partial resection with the unroofing technique for reliable tissue diagnosis of upper GI subepithelial tumors originating from the muscularis propria on EUS (with video). Gastrointest Endosc. 2010;71(1):188–94.PubMedCrossRef
26.
Zurück zum Zitat Binmoeller KF, Shah JN, Bhat YM, Kane SD. Suck-ligate-unroof-biopsy by using a detachable 20-mm loop for the diagnosis and therapy of small subepithelial tumors (with video). Gastrointest Endosc. 2014;79(5):750–5.PubMedCrossRef Binmoeller KF, Shah JN, Bhat YM, Kane SD. Suck-ligate-unroof-biopsy by using a detachable 20-mm loop for the diagnosis and therapy of small subepithelial tumors (with video). Gastrointest Endosc. 2014;79(5):750–5.PubMedCrossRef
27.
Zurück zum Zitat Sanaei O, Fernández-Esparrach G, De La Serna-Higuera C, Carrara S, Kumbhari V, El Zein MH, et al. EUS-guided 22-gauge fine needle biopsy versus single-incision with needle knife for the diagnosis of upper gastrointestinal subepithelial lesions: a randomized controlled trial. Endosc Int Open. 2020;08(03):E266–73.CrossRef Sanaei O, Fernández-Esparrach G, De La Serna-Higuera C, Carrara S, Kumbhari V, El Zein MH, et al. EUS-guided 22-gauge fine needle biopsy versus single-incision with needle knife for the diagnosis of upper gastrointestinal subepithelial lesions: a randomized controlled trial. Endosc Int Open. 2020;08(03):E266–73.CrossRef
28.
Zurück zum Zitat •• Giri S, Afzalpurkar S, Angadi S, Sundaram S. Mucosal incision-assisted biopsy versus endoscopic ultrasound-assisted tissue acquisition for subepithelial lesions: a systematic review and meta-analysis. Clin Endosc. 2022;55(5):615–25. Systematic review and meta-analysis including seven studies assessing the use of MIAB for diagnosis of gastrointestinal subepithelial lesions. Indicated that performance of MIAB was comparable to EUS-guided tissue acquisition and performance may be superior for lesions <2 cm.PubMedPubMedCentralCrossRef •• Giri S, Afzalpurkar S, Angadi S, Sundaram S. Mucosal incision-assisted biopsy versus endoscopic ultrasound-assisted tissue acquisition for subepithelial lesions: a systematic review and meta-analysis. Clin Endosc. 2022;55(5):615–25. Systematic review and meta-analysis including seven studies assessing the use of MIAB for diagnosis of gastrointestinal subepithelial lesions. Indicated that performance of MIAB was comparable to EUS-guided tissue acquisition and performance may be superior for lesions <2 cm.PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Iwamuro M, Tanaka T, Kanzaki H, Kawano S, Kawahara Y, Okada H. Esophageal granular cell tumors can be differentiated from leiomyomas using endoscopic ultrasonography. Intern Med. 2018;57(11):1509–15.PubMedPubMedCentralCrossRef Iwamuro M, Tanaka T, Kanzaki H, Kawano S, Kawahara Y, Okada H. Esophageal granular cell tumors can be differentiated from leiomyomas using endoscopic ultrasonography. Intern Med. 2018;57(11):1509–15.PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Sun LJ, Chen X, Dai YN, Xu CF, Ji F, Chen LH, et al. Endoscopic ultrasonography in the diagnosis and treatment strategy choice of esophageal leiomyoma. Clinics. 2017;72(4):197–201.PubMedPubMedCentralCrossRef Sun LJ, Chen X, Dai YN, Xu CF, Ji F, Chen LH, et al. Endoscopic ultrasonography in the diagnosis and treatment strategy choice of esophageal leiomyoma. Clinics. 2017;72(4):197–201.PubMedPubMedCentralCrossRef
31.
Zurück zum Zitat Taşkın OÇ, Armutlu A, Adsay V, Aslan F, Kapran Y. Clinicopathologic and immunohistochemical characteristics of upper gastrointestinal leiomyomas harboring interstitial cells of Cajal: a potential mimicker of gastrointestinal stromal tumor. Ann Diagn Pathol. 2020;45:151476.PubMedCrossRef Taşkın OÇ, Armutlu A, Adsay V, Aslan F, Kapran Y. Clinicopathologic and immunohistochemical characteristics of upper gastrointestinal leiomyomas harboring interstitial cells of Cajal: a potential mimicker of gastrointestinal stromal tumor. Ann Diagn Pathol. 2020;45:151476.PubMedCrossRef
32.
Zurück zum Zitat • Wu CE, Tzen CY, Wang SY, Yeh CN. Clinical diagnosis of gastrointestinal stromal tumor (GIST): from the molecular genetic point of view. Cancers. 2019;11(5):679. Summary and suggested algorithm for diagnosis of gastrointestinal stromal tumors using immunohistochemistry and genetic testing.PubMedPubMedCentralCrossRef • Wu CE, Tzen CY, Wang SY, Yeh CN. Clinical diagnosis of gastrointestinal stromal tumor (GIST): from the molecular genetic point of view. Cancers. 2019;11(5):679. Summary and suggested algorithm for diagnosis of gastrointestinal stromal tumors using immunohistochemistry and genetic testing.PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Novelli M, Rossi S, Rodriguez-Justo M, Taniere P, Seddon B, Toffolatti L, et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 2010;57(2):259–70.PubMedCrossRef Novelli M, Rossi S, Rodriguez-Justo M, Taniere P, Seddon B, Toffolatti L, et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 2010;57(2):259–70.PubMedCrossRef
34.
Zurück zum Zitat Jiao J, Fan X, Luo L, Zhao W, Zheng Z, Chen X, et al. Efficacy of endoscopic ultrasound and endoscopic resection for esophageal schwannoma. Scand J Gastroenterol. 2023;58(8):963–9.PubMedCrossRef Jiao J, Fan X, Luo L, Zhao W, Zheng Z, Chen X, et al. Efficacy of endoscopic ultrasound and endoscopic resection for esophageal schwannoma. Scand J Gastroenterol. 2023;58(8):963–9.PubMedCrossRef
35.
Zurück zum Zitat Hou YY, Tan YS, Xu JF, Wang XN, Lu SH, Ji Y, et al. Schwannoma of the gastrointestinal tract: a clinicopathological, immunohistochemical and ultrastructural study of 33 cases. Histopathology. 2006;48(5):536–45.PubMedCrossRef Hou YY, Tan YS, Xu JF, Wang XN, Lu SH, Ji Y, et al. Schwannoma of the gastrointestinal tract: a clinicopathological, immunohistochemical and ultrastructural study of 33 cases. Histopathology. 2006;48(5):536–45.PubMedCrossRef
37.
Zurück zum Zitat Rasalkar DD, Chiu PWY, Teoh AYB, Chu WCW. Oesophageal haemangioma: imaging characteristics of this rare condition. Hong Kong Med J Xianggang Yi Xue Za Zhi. 2010;16(3):230–1.PubMed Rasalkar DD, Chiu PWY, Teoh AYB, Chu WCW. Oesophageal haemangioma: imaging characteristics of this rare condition. Hong Kong Med J Xianggang Yi Xue Za Zhi. 2010;16(3):230–1.PubMed
38.
Zurück zum Zitat Chen YY, Lin CM, Chen YF. Endoscopic and radiologic appearance of giant esophageal hemangioma. Endoscopy. 2015;47(S01):E45-6.PubMed Chen YY, Lin CM, Chen YF. Endoscopic and radiologic appearance of giant esophageal hemangioma. Endoscopy. 2015;47(S01):E45-6.PubMed
39.
Zurück zum Zitat Arizono E, Tajima Y, Yoshimura M, Saito K, Itoi T. Giant esophageal hemangioma diagnosed by 99mTc-HSA-D scintigraphy following equivocal CT, MRI, and endoscopy. Radiol Case Rep. 2021;16(5):1023–7.PubMedPubMedCentralCrossRef Arizono E, Tajima Y, Yoshimura M, Saito K, Itoi T. Giant esophageal hemangioma diagnosed by 99mTc-HSA-D scintigraphy following equivocal CT, MRI, and endoscopy. Radiol Case Rep. 2021;16(5):1023–7.PubMedPubMedCentralCrossRef
40.
Zurück zum Zitat Ryu DG, Kim SJ, Choi CW, Hwang CS, Kim HW, Park SB, et al. Combination conventional endoscopy and endoscopic ultrasound can differentiate between esophageal granular cell tumors and leiomyomas. Medicine (Baltimore). 2022;101(45):e31435.PubMedCrossRef Ryu DG, Kim SJ, Choi CW, Hwang CS, Kim HW, Park SB, et al. Combination conventional endoscopy and endoscopic ultrasound can differentiate between esophageal granular cell tumors and leiomyomas. Medicine (Baltimore). 2022;101(45):e31435.PubMedCrossRef
41.
Zurück zum Zitat Shi Y, Chai N, Zhong L, Li L, Zou J, Xiang J, et al. Experience with esophageal granular cell tumors: clinical and endoscopic analysis of 22 cases. Dig Dis Sci. 2021;66(4):1233–9.PubMedCrossRef Shi Y, Chai N, Zhong L, Li L, Zou J, Xiang J, et al. Experience with esophageal granular cell tumors: clinical and endoscopic analysis of 22 cases. Dig Dis Sci. 2021;66(4):1233–9.PubMedCrossRef
42.
Zurück zum Zitat Goenka AH, Sharma S, Ramachandran V, Chattopadhyay TK, Ray R. Giant fibrovascular polyp of the esophagus: report of a case. Surg Today. 2011;41(1):120–4.PubMedCrossRef Goenka AH, Sharma S, Ramachandran V, Chattopadhyay TK, Ray R. Giant fibrovascular polyp of the esophagus: report of a case. Surg Today. 2011;41(1):120–4.PubMedCrossRef
43.
Zurück zum Zitat Pinto A, Abastado B, Cattan P. An esophageal tumor unlike others: the fibrovascular polyp. J Visc Surg. 2019;156(3):271–3.PubMedCrossRef Pinto A, Abastado B, Cattan P. An esophageal tumor unlike others: the fibrovascular polyp. J Visc Surg. 2019;156(3):271–3.PubMedCrossRef
44.
Zurück zum Zitat Kim M, Chae KJ, Kim JH, Han YH. Giant fibrovascular polyp mimicking esophageal malignancy on 18F-FDG PET/CT. Clin Nucl Med. 2023;48(12):1091–2.PubMedCrossRef Kim M, Chae KJ, Kim JH, Han YH. Giant fibrovascular polyp mimicking esophageal malignancy on 18F-FDG PET/CT. Clin Nucl Med. 2023;48(12):1091–2.PubMedCrossRef
45.
Zurück zum Zitat Graham RP, Yasir S, Fritchie KJ, Reid MD, Greipp PT, Folpe AL. Polypoid fibroadipose tumors of the esophagus: “giant fibrovascular polyp” or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases. Mod Pathol. 2018;31(2):337–42.PubMedCrossRef Graham RP, Yasir S, Fritchie KJ, Reid MD, Greipp PT, Folpe AL. Polypoid fibroadipose tumors of the esophagus: “giant fibrovascular polyp” or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases. Mod Pathol. 2018;31(2):337–42.PubMedCrossRef
46.
47.
Zurück zum Zitat Birkness-Gartman JE, Wangsiricharoen S, Lazar AJ, Gross JM. Oesophageal glomus tumours: rare neoplasms with aggressive clinical behaviour. Histopathology. 2023;82(7):1048–55.PubMedCrossRef Birkness-Gartman JE, Wangsiricharoen S, Lazar AJ, Gross JM. Oesophageal glomus tumours: rare neoplasms with aggressive clinical behaviour. Histopathology. 2023;82(7):1048–55.PubMedCrossRef
48.
Zurück zum Zitat Modi C, Shah A, Depasquale JR, Shah N, Spira RS. A large prolapsed inflammatory fibroid polyp of the esophagus: an unusual presentation. Gastroenterol Hepatol. 2013;9(5):322–5. Modi C, Shah A, Depasquale JR, Shah N, Spira RS. A large prolapsed inflammatory fibroid polyp of the esophagus: an unusual presentation. Gastroenterol Hepatol. 2013;9(5):322–5.
49.
Zurück zum Zitat Yamamoto M, Nishida T, Nakamatsu D, Adachi S, Inada M. Endoscopic findings of esophageal gland duct adenoma resected by endoscopic submucosal dissection. Gastrointest Endosc. 2020;92(4):961–2.PubMedCrossRef Yamamoto M, Nishida T, Nakamatsu D, Adachi S, Inada M. Endoscopic findings of esophageal gland duct adenoma resected by endoscopic submucosal dissection. Gastrointest Endosc. 2020;92(4):961–2.PubMedCrossRef
50.
Zurück zum Zitat Nie L, Wu HY, Shen YH, Fan XS, Sun Q, Huang Q, et al. Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature: esophageal submucosal gland duct adenoma. Dis Esophagus. 2016;29(8):1048–53.PubMedCrossRef Nie L, Wu HY, Shen YH, Fan XS, Sun Q, Huang Q, et al. Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature: esophageal submucosal gland duct adenoma. Dis Esophagus. 2016;29(8):1048–53.PubMedCrossRef
51.
Zurück zum Zitat Wong MW, Bair MJ, Shih SC, Chu CH, Wang HY, Wang TE, et al. Using typical endoscopic features to diagnose esophageal squamous papilloma. World J Gastroenterol. 2016;22(7):2349–56.PubMedPubMedCentralCrossRef Wong MW, Bair MJ, Shih SC, Chu CH, Wang HY, Wang TE, et al. Using typical endoscopic features to diagnose esophageal squamous papilloma. World J Gastroenterol. 2016;22(7):2349–56.PubMedPubMedCentralCrossRef
52.
Zurück zum Zitat Iwamuro M, Okamoto Y, Kawano S, Okada H. Esophageal papilloma detected by positron emission tomography. Intern Med. 2020;59(7):1003–4.PubMedCrossRef Iwamuro M, Okamoto Y, Kawano S, Okada H. Esophageal papilloma detected by positron emission tomography. Intern Med. 2020;59(7):1003–4.PubMedCrossRef
Metadaten
Titel
The Diagnostic Approach of Benign Esophageal Tumors: A Narrative Review
verfasst von
Alex R. Jones, MD
Preksha Vankawala, MD
Tarek Sawas, MD, MPH
Publikationsdatum
15.03.2024
Verlag
Springer US
Erschienen in
Current Treatment Options in Gastroenterology
Print ISSN: 1092-8472
Elektronische ISSN: 1534-309X
DOI
https://doi.org/10.1007/s11938-024-00443-7

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

17.05.2024 Plötzlicher Herztod Nachrichten

Ein signifikanter Anteil der Fälle von plötzlichem Herztod ist genetisch bedingt. Um ihre Verwandten vor diesem Schicksal zu bewahren, sollten jüngere Personen, die plötzlich unerwartet versterben, ausnahmslos einer Autopsie unterzogen werden.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

17.05.2024 Herzinsuffizienz Nachrichten

Bei adipösen Patienten mit Herzinsuffizienz des HFpEF-Phänotyps ist Semaglutid von symptomatischem Nutzen. Resultiert dieser Benefit allein aus der Gewichtsreduktion oder auch aus spezifischen Effekten auf die Herzinsuffizienz-Pathogenese? Eine neue Analyse gibt Aufschluss.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.