The early life growth of head circumference, weight, and height in infants with autism spectrum disorders: a systematic review

Autism spectrum disorder (ASD) is a neurodevelopmental condition influencing one in 59 children in the world. Along with behavior problems, ASD is accompanied with sleep complications, seizures, gastrointestinal difficulties, and mental health concerns that can intensely affect the quality of life of children and their families [1]. Intellectual disability or low verbal ability were also reported in around one-third of children with ASD [1]. Timely identification of developmental disorders is vital to the well-being of children. American Academy of Pediatrics (AAP) suggests that developmental surveillance and standardized screening tests be considered for ASD at 18 and 24 months of age, at every health supervision visit [2].

The precise cause of ASD is mostly unknown [3]. According to evidence, multiple risk factors including genetic, environmental, immunological, and perinatal factors may contribute to the ASD pathogenesis [3‐6]. On the other hand, both genetics and environmental factors early in development have role in the etiology of autism [7]. However, some of the evidence supporting a significant contribution of environmental factors to autism risk [6]. Features of autism may be detected in early childhood, but the diagnosis of autism is usually not made until much later [5]. Recently, ASD detection strategies focus on early risk markers and growth abnormalities during the early years of life have often been paid attention, to in this direction [8‐10].

Growth assessments and standard growth patterns are the gold standard diagnostic tests by which clinicians evaluate the health and physical and emotional well-being of a child. Height, weight, and head circumference (HC) are the main components of anthropometry for infants and toddlers less than two years of age [11]. Reliable sequential anthropometric assessments can help recognize underlying medical, nutritional, or social problems in infants and children [12].

Poor growth during infancy or childhood may contribute to adverse health outcomes in adults [13, 14], hence prevention of growth retardation at these periods of life may have both short- and long-term health advantages [15, 16]. On contrary, several observational investigations have indicated that early life (under two years) accelerated or too fast growth may adversely contribute to long-term health outcomes such as increasing the risk of obesity and chronic diseases [17‐19]. In preterm infants, the growth acceleration may be beneficial for later neurodevelopment [17], but it may affect contradictory in healthy term infants. Recently, infancy growth accelerated has become a major focus of research.

Increased body growth, including weight and height, during infancy, has been suggested as a feature of ASD by several studies [9, 20]. In addition, macrocephaly and abnormal acceleration in head growth during the early stages of postnatal development have been proposed as a discerning feature of ASD, by some other investigations [21, 22]. However, the findings were inconsistent across the studies and it is not yet definitively known whether accelerated HC and body growth during infancy are associated with ASD incidents. Moreover, most studies have focused on the physical growth in older children and adolescents with ASD. Best to our knowledge, there is no comprehensive study to review systematically the association between early life growth of HC, weight, and height with ASD incidents in infants. Therefore, the present study was performed to summarize the existing literature regarding the association between early life growth of HC, weight, and height with ASD incidents in infants.

The protocol of this study was approved and registered by the Research Vice-Chancellor of Tabriz University of Medical Sciences (ethical code: IR.TBZMED.REC.1400.1243).

The findings of the present study showed that rapid growth of weight, height, and HC during infancy was associated with an enhanced risk of ASD developing. The previous research also emphasis the importance of assessing neonatal anthropometric measures such as weight and HC growth [33‐35]. Some studies confirm the validity of HC growth as a potential biomarker of normal and abnormal early child development [35, 36]. Recently, it has been reported that an abnormality in factors such as hormone levels, metabolism, and growth or neurotrophic factors may predispose a subject to overall acceleration of growth as well as ASD [22, 36, 37]. Neurotrophins abnormalities, which regulate the metabolism of glucose, may cause accelerated growth in HC and body size [38] and also improve neuronal growth and survival [39]. Liu et al. [40] performed a comprehensive systematic review on the changes in peripheral neurotrophic factors in autistic children and revealed strong evidence that the levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) in peripheral blood of autistic children were higher than those in healthy controls, establishment the evidence that neurotrophic factors play critical roles in ASD onset and/or development. However, they found no significant associations between neurotrophin-3 (NT-3) or neurotrophin-4 (NT-4) and ASD [40]. It has been reported that overgrowth of the brain volume in early ASD children is largely due to the augmented proliferation of neural progenitor cells [43]. Neurotrophic factors have a positive role in the embryonic neural progenitor cells proliferation [42]. Importantly, the BDNF level is temporally regulated during development that has been shown to be required for the proper development and functions of neuronal [43]. Therefore, it is likely that in the early life of ASD children, abnormal regulation of BDNF cause the subsequent long-term changes in structure and function of the brain, such as accelerating its growth. BDNF has also similar effects in other psychiatric disorders [44].

According to the previous evidence, abnormal secretion of some hormones, such as adiponectin, leptin, ghrelin, insulin, and IGF-1 may cause changes in the growth process, especially in early life, and may be associated with the risk of autism [45‐50]. Adipokines, cytokines secreted mostly by adipose tissue, may have a widespread effect and function on brain health [51]. Rodrigues et al. found significant changes in the adipokines plasma levels in ASD patients [52]. Many adipokines such as interleukin-8 [53], interleukin-6 (IL-6) [54], IL-10 [55], leptin [56], tumor necrosis factor-alpha (TNF-α) [57], omentin [58], resistin, and adiponectin [59] have been shown to be associated with ASD. Adiponectin is an adipocyte-derived circulating protein that based on recent evidence may have a role in the pathophysiology of autism [60]. Fujita-Shimizu et al. indicated that the serum levels of adiponectin were significantly lower in the individuals with autism than in normal subjects [61]. However, the role of adiponectin on the early life growth of autistic infants is not clear.

Leptin is another hormone whose abnormality in its release may be contributed to the association between rapid growth and ASD. Recent works found elevated plasma leptin levels in children with autism compared to typically developing controls [52, 62, 63]. There are some reasons for the involvement of leptin in the neuropathology of ASD. Leptin can cross the blood-brain barrier through active transport [64]. Moreover, it has been reported that proinflammatory cytokines can mediate the rapid postnatal growth of ASD [65]. Raghavan et al. indicated the mediating effect of leptin in extremely rapid weight gain during infancy in ASD children [56]. Although they did not analyze HC, weight is the strongest predictor of HC during most of the infancy [22]. In agreement with this, animal models showed that rapid catch-up growth in early childhood is connected with leptin resistance [66]. Beyond leptin’s role in weight gain of postnatal, this pleiotropic cytokine has an essential function in the neurodevelopment regulation of including neural differentiation, promoting migration of neuronal lineage cells to the cortical plate, synaptic plasticity, and neuron excitability, [62, 63, 67].

It is well known that ghrelin has a significant role in the growth and development of infants [68‐70]. Al-Zaid et al. showed that the plasma levels of ghrelin were significantly decreased in the autism group compared with healthy controls and revealed also a significant negative association between ghrelin and HC [50]. It is intriguing the fact that autistic children despite low ghrelin levels have increased weight; this could be suggesting a drastic disturbance in the central processing of these peripheral signals. The involvement of many other hormones which may have functions in body weight management is another possible explanation [50].

Insulin-like growth factor-1 (IGF-1) is a neurotrophin that regulates somatic growth and metabolism and myelination and brain growth [71]. Lower plasma IGF-1 and growth hormone-binding protein (GHBP) was observed in autistic children [46], and IGF-1 levels were positively correlated with HC [46]. Li et al. also demonstrated that the ASD group had a significantly lower serum level of IGF- 1 and IGFBP (IGF binding protein)-3 than the control group [72]. The beneficial effects of IGF-1 for treating ASD are due to the potent effects of IGF-1 on synaptic maintenance, function, and plasticity. Based on these findings, the reduction in serum IGF-1 levels in early childhood may be associated with the development of ASD, but the mechanism of the association between decreased IGF-1 levels and increased HC, weight, and height in infants with autism has not yet been elucidated. Abnormal regulation of some hormones such as BDNF, IGF-1, leptin, and ghrelin may be associated with the accelerated growth of infants. However, genes related to head circumference and behavioral development, such as PTEN, might have a role in ASD [73‐75]. Fu et al. revealed that some of the PTEN variant and ASD genetic background affected genes involved in neurogenesis, neural development, and synapse signaling and contribute to cellular features consistent with ASD associated with macrocephaly [74]. Moreover, mutations in the regulator genes of mTORC1 result in ASD-like phenotypes through the disruption of the mTORC1-mediated signaling [75].

Macrocephaly is one of the most common physical findings was achieved in autistic individuals [76]. Reported rates of macrocephaly in autistic children vary, with an average rate of 20%. However, 83.3% of the studies included in this review showed that autistic children at or shortly after birth usually did not have macrocephaly and had a similar HC percentile distribution as the general population. Therefore, an abnormal acceleration in head growth during the earliest stages of postnatal development, independent of macrocephaly, may be a risk factor related with the development of ASD [21].

Timely evaluation and early detection of ASD among young children should be an important public health goal [77] because evidence showed that early treatment and services for ASD links with improved outcomes [40, 78, 79]. It should be considered that the findings were obtained from the studies with various follow-up times and different time points for assessing growth and outcomes and were concluded from retrospective and prospective data. Moreover, racial difference between the infants may be have a role in these findings. Nevertheless, early life assessment of anthropometric measures is suggested.

More than 91% of the studies included in this systematic review revealed that rapid growth of HC, weight, or height during infancy probably was associated with the risk of ASD. Therefore, these measurements might be helpful as initial predictive biomarkers for the risk of developing ASD. In addition, these measurements may be a useful and cost-effective method in helping to diagnose the risk of ASD in situations where there isn’t access to magnetic resonance imaging technology. However, these measures are not replaceable with aspects that neuroimaging exams can achieve. Long-term prospective cohort studies are required to determine the association between accelerated growth in the early life and ASD risk.