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European Archives of Oto-Rhino-Laryngology

Erschienen in:

22.12.2023 | Review Article

The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review

verfasst von: Gabriel Rossi Francisco, Júlia Leão Batista Simões, Geórgia de Carvalho Braga, Paulo Henrique Guerra, Margarete Dulce Bagatini

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2024

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Abstract

Purpose

Prader–Willi syndrome is a serious genetic condition, capable of causing endocrinological imbalance, which has as one of its main treatments the growth hormone therapy. However, this therapy still causes some uncertainty concerning its effects on the respiratory parameters of those patients, especially in cases of obstructive sleep apnea, therefore, presenting a need for the analysis of the relationship between the therapy and the otolaryngologic condition.

Methods

A systematic review following the PRISMA model was developed, with searches for keywords made in the databases PubMed (MEDLINE), Scopus, and Web of Science and registration in the PROSPERO platform (CRD42023404250).

Results

Three randomized controlled trials were considered eligible for inclusion in the review. None of the studies demonstrated statistically significant modifications in the obstructive sleep apnea parameters of Prader–Willi patients related to the growth hormone administration.

Conclusions

Growth hormone therapy is safe for Prader–Willi syndrome patients when analyzing their obstructive sleep apnea parameters.

Butler MG, Miller JL, Forster JL (2019) Prader–Willi syndrome—clinical genetics, diagnosis and treatment approaches: an update. Curr Pediatr Rev 15:207–244. https://doi.org/10.2174/1573396315666190716120925CrossRefPubMedPubMedCentral

Cassidy SB, Schwartz S, Miller JL, Driscoll DJ (2012) Prader–Willi syndrome. Genet Med 14:10–26. https://doi.org/10.1038/gim.0b013e31822bead0CrossRefPubMed

Angulo MA, Butler MG, Cataletto ME (2015) Prader–Willi syndrome: a review of clinical, genetic, and endocrine findings. J Endocrinol Investig 38:1249–1263. https://doi.org/10.1007/s40618-015-0312-9CrossRef

Jordan AS, McSharry DG, Malhotra A (2014) Adult obstructive sleep apnoea. Lancet 383:736–747. https://doi.org/10.1016/S0140-6736(13)60734-5CrossRefPubMed

Vogt K, Emerick J (2015) Growth hormone therapy in adults with Prader–Willi syndrome. Diseases 3:56–67. https://doi.org/10.3390/diseases3020056CrossRefPubMedPubMedCentral

Deal CL, Tony M, Höybye C et al (2013) Growth Hormone Research Society Workshop Summary: consensus guidelines for recombinant human growth hormone therapy in Prader–Willi syndrome. J Clin Endocrinol Metab 98:E1072–E1087. https://doi.org/10.1210/jc.2012-3888CrossRefPubMedPubMedCentral

Tauber M, Diene G, Molinas C, Hébert M (2008) Review of 64 cases of death in children with Prader–Willi syndrome (PWS). Am J Med Genet A 146A:881–887. https://doi.org/10.1002/ajmg.a.32131CrossRefPubMed

Ouzzani M, Hammady H, Fedorowicz Z et al (2016) Rayyan—a web and mobile app for systematic reviews. Syst Rev 5:210. https://doi.org/10.1186/s13643-016-0384-4CrossRefPubMedPubMedCentral

THOMAS BH Effective Public Healthcare Panacea Project. In: https://www.ephpp.ca/quality-assessment-tool-for-quantitative-studies/?/. Accessed 27 Apr 2023

10.

Donze SH, de Weerd AW, van den Bossche RAS et al (2019) Sleep-related breathing disorders in young adults with Prader–Willi syndrome: a placebo-controlled, crossover GH trial. J Clin Endocrinol Metab 104:3931–3938. https://doi.org/10.1210/jc.2019-00391CrossRefPubMed

11.

Haqq AM, Stadler DD, Jackson RH et al (2003) Effects of growth hormone on pulmonary function, sleep quality, behavior, cognition, growth velocity, body composition, and resting energy expenditure in Prader–Willi syndrome. J Clin Endocrinol Metab 88:2206–2212. https://doi.org/10.1210/jc.2002-021536CrossRefPubMed

12.

Shukur HH, Hussain-Alkhateeb L, Farholt S et al (2021) Effects of growth hormone treatment on sleep-related parameters in adults with Prader–Willi syndrome. J Clin Endocrinol Metab 106:e3634–e3643. https://doi.org/10.1210/clinem/dgab300CrossRefPubMedPubMedCentral

13.

Miller J, Silverstein J, Shuster J et al (2006) Short-term effects of growth hormone on sleep abnormalities in Prader–Willi syndrome. J Clin Endocrinol Metab 91:413–417. https://doi.org/10.1210/jc.2005-1279CrossRefPubMed

14.

Van VG, Deal CL, Crock PA et al (2004) Sudden death in growth hormone-treated children with Prader–Willi syndrome. J Pediatr 144:129–131. https://doi.org/10.1016/j.jpeds.2003.09.049CrossRef

15.

Zimmermann M, Laemmer C, Woelfle J et al (2020) Sleep-Disordered Breathing In Children with Prader–Willi syndrome in relation to growth hormone therapy onset. Horm Res Paediatr 93:85–93. https://doi.org/10.1159/000506943CrossRefPubMed

16.

Whittington JE, Holland AJ, Webb T (2015) Ageing in people with Prader–Willi syndrome: mortality in the UK population cohort and morbidity in an older sample of adults. Psychol Med 45:615–621. https://doi.org/10.1017/S0033291714001755CrossRefPubMed

17.

Miller J, Wagner M (2013) Prader–Willi syndrome and sleep-disordered breathing. Pediatr Ann. https://doi.org/10.3928/00904481-20130924-10CrossRefPubMed

18.

Tan H-L, Urquhart DS (2017) Respiratory complications in children with Prader–Willi syndrome. Paediatr Respir Rev 22:52–59. https://doi.org/10.1016/j.prrv.2016.08.002CrossRefPubMed

19.

Nixon GM, Rodda CP, Davey MJ (2011) Longitudinal association between growth hormone therapy and obstructive sleep apnea in a child with Prader–Willi syndrome. J Clin Endocrinol Metab 96:29–33. https://doi.org/10.1210/jc.2010-1445CrossRefPubMed

20.

Einfeld SL, Tonge BJ, Gray K, Taffe J (2006) Evolution of symptoms and syndromes of psychopathology in young people with mental retardation. Elsevier, New York, pp 247–265

Titel: The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review
verfasst von: Gabriel Rossi Francisco
Júlia Leão Batista Simões
Geórgia de Carvalho Braga
Paulo Henrique Guerra
Margarete Dulce Bagatini
Publikationsdatum: 22.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2024
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08406-x

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The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review