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Erschienen in: Basic Research in Cardiology 1/2023

01.12.2023 | Review

The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury

verfasst von: Bridgette Hartley, Wesam Bassiouni, Richard Schulz, Olivier Julien

Erschienen in: Basic Research in Cardiology | Ausgabe 1/2023

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Abstract

Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemia–reperfusion injury caused by the reintroduction of blood supply to ischemic cardiac muscle. The short and long-term damage that occurs due to ischemia–reperfusion injury is partly due to the proteolysis of diverse protein substrates inside and outside of cardiomyocytes. Ischemia–reperfusion activates several diverse intracellular proteases, including, but not limited to, matrix metalloproteinases, calpains, cathepsins, and caspases. This review will focus on the biological roles, intracellular localization, proteolytic targets, and inhibitors of these proteases in cardiomyocytes following ischemia–reperfusion injury. Recognition of the intracellular function of each of these proteases includes defining their activation, proteolytic targets, and their inhibitors during myocardial ischemia–reperfusion injury. This review is a step toward a better understanding of protease activation and involvement in ischemic heart disease and developing new therapeutic strategies for its treatment.
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Metadaten
Titel
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
verfasst von
Bridgette Hartley
Wesam Bassiouni
Richard Schulz
Olivier Julien
Publikationsdatum
01.12.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Basic Research in Cardiology / Ausgabe 1/2023
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-023-01007-z

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