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Head and Neck Pathology
Erschienen in: Head and Neck Pathology 1/2023

16.03.2023 | Special Issue: Top Ten Head and Neck Differentials

Top 10 Nested Pattern Head and Neck Lesions to Notice

verfasst von: Abberly Lott Limbach, Deborah J. Chute

Erschienen in: Head and Neck Pathology | Ausgabe 1/2023

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Abstract

Background

Nested is defined as “cellular clusters arranged in small groupings with intervening vascular or stromal networks, lacking lumens or glandular formation.” Using this definition, multiple neoplastic and non-neoplastic lesions of the head and neck come into the differential. We have broadly organized the differential diagnosis of “nested” tumors into entities with neuroendocrine differentiation, squamous differentiation, thyroid follicular cell differentiation, and other lesions.

Methods

Review.

Results

Many different entities have a nested appearance and the morphologic, immunohistochemical, clinical, and radiographic features contribute to the differential diagnosis. The different tumors covered in this review include neuroendocrine neoplasms, paraganglioma, middle ear neuroendocrine tumor (formerly known as middle ear adenoma), medullary thyroid carcinoma, poorly differentiated thyroid carcinoma, olfactory neuroblastoma, ectopic pituitary neuroendocrine tumor, hyalinizing trabecular tumor, solid subtype of papillary thyroid carcinoma, solid cell nests/C-cell hyperplasia, necrotizing sialometaplasia, and meningioma.

Conclusion

In this review, we discuss the morphologic and immunohistochemical features of the covered entities as a guide to differential diagnosis when nested-patterned head and neck lesions are encountered.
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Metadaten
Titel
Top 10 Nested Pattern Head and Neck Lesions to Notice
verfasst von
Abberly Lott Limbach
Deborah J. Chute
Publikationsdatum
16.03.2023
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2023
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-023-01534-0

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