Introduction
Subjects and methods
Study population
Assessment of body weight, blood pressure and biochemical parameters
Assessment of history of metabolic diseases
Assessment of CAP (outcome)
Definition of metabolically healthy status and unhealth status
Statistical analysis
Results
Variables | Normal weight (18.5 ≤ BMI ≤ 23.9 kg/m2) | Overweight (BMI ≥ 24.0 kg/m2) | P value |
---|---|---|---|
Sample number | 7512 | 2324 | – |
Age, y | 35.6 ± 8.9 | 36.3 ± 9.3 | < 0.001 |
Sex, M/F, % | 34.9/65.1 | 63.1/36.9 | < 0.001 |
BMI, kg/m2 | 21.3 ± 1.5 | 25.8 ± 1.7 | < 0.001 |
FBG, mmol/L | 4.8 ± 0.4 | 4.8 ± 0.4 | < 0.001 |
HbA1c, % | 5.1 ± 0.3 | 5.2 ± 0.3 | < 0.001 |
SBP, mmHg | 108.2 ± 9.7 | 112.8 ± 8.7 | < 0.001 |
DBP, mmHg | 67.1 ± 6.9 | 69.6 ± 6.3 | < 0.001 |
TC, mmol/L | 4.4 ± 0.6 | 4.4 ± 0.6 | 0.08 |
TG, mmol/L | 0.8 ± 0.3 | 1.0 ± 0.3 | < 0.001 |
HDL-C, mmol/L | 1.5 ± 0.3 | 1.3 ± 0.3 | < 0.001 |
LDL-C, mmol/L | 2.4 ± 0.5 | 2.6 ± 0.5 | < 0.001 |
Hs-CRP, mg/L* | 0.36 (0.2, 0.7) | 0.7 (0.38, 1.34) | < 0.001 |
eGFR, ml/min/1.73m2 | 112.7 ± 12.3 | 109.8 ± 12.6 | < 0.001 |
Outcome | Metabolically healthy normal weight | Metabolically healthy overweight |
---|---|---|
(BMI < 24.0 kg/m2) | (BMI ≥ 24.0 kg/m2) | |
HBP | ||
Number of participants | 7512 | 2324 |
Incident case | 2400 | 1177 |
Model 1 | Ref (1.0) | 1.50 (1.4, 1.61) |
Model 2 | Ref (1.0) | 1.49 (1.39, 1.6) |
Model 3 | Ref (1.0) | 1.23 (1.14, 1.33) |
IGR | ||
Number of participants | 7512 | 2324 |
Incident case | 1394 | 594 |
Model 1 | Ref (1.0) | 1.36 (1.24, 1.51) |
Model 2 | Ref (1.0) | 1.31 (1.2, 1.49) |
Model 3 | Ref (1.0) | 1.15 (1.04, 1.28) |
High TC | ||
Number of Participants | 7512 | 2,324 |
Incident case | 836 | 266 |
Model 1 | Ref (1.0) | 1.08 (0.94, 1.25) |
Model 2 | Ref (1.0) | 1.07 (0.93, 1.24) |
Model 3 | Ref (1.0) | 1.03 (0.89, 1.19) |
High TG | ||
Number of participants | 7512 | 2324 |
Incident case | 908 | 595 |
Model 1 | Ref (1.0) | 1.79 (1.6, 1.99) |
Model 2 | Ref (1.0) | 1.77 (1.59, 1.97) |
Model 3 | Ref (1.0) | 1.12 (1.001, 1.25) |
High LDL-C | ||
Number of participants | 7512 | 2324 |
Incident case | 1264 | 550 |
Model 1 | Ref (1.0) | 1.31 (1.18, 1.45) |
Model 2 | Ref (1.0) | 1.3 (1.17, 1.44) |
Model 3 | Ref (1.0) | 0.99 (0.89, 1.11) |
Low HDL-C | ||
Number of participants | 7512 | 2324 |
Incident case | 371 | 238 |
Model 1 | Ref (1.0) | 1.78 (1.5, 2.1) |
Model 2 | Ref (1.0) | 1.75 (1.48, 2.08) |
Model 3 | Ref (1.0) | 0.99 (0.83, 1.18) |
Models | Metabolically healthy normal weight | Metabolically healthy overweight | ||
---|---|---|---|---|
(n = 7512, BMI < 24.0 kg/m2) | (n = 2324, BMI ≥ 24.0 kg/m2) | |||
Stable | Transition to HBP | Stable | Transition to HBP | |
Number of participants | 5112 | 2400 | 1147 | 1177 |
CAP case | 35 | 50 | 14 | 34 |
Model 1 | Ref (1.0) | 1.64 (1.05, 2.55) | 1.24 (0.66, 2.31) | 2.35 (1.45, 3.83) |
Model 2 | Ref (1.0) | 1.62 (1.04, 2.53) | 1.22 (0.62, 2.29) | 2.36 (1.45, 3.85) |
Model 3 | Ref (1.0) | 1.69 (1.06, 2.68) | 1.18 (0.62, 2.23) | 2.29 (1.35, 3.87) |
Stable | Transition to IGR | Stable | Transition to IGR | |
---|---|---|---|---|
Number of participants | 6118 | 1394 | 1730 | 594 |
CAP case | 56 | 29 | 24 | 24 |
Model 1 | Ref (1.0) | 1.22 (0.78, 1.93) | 1.18 (0.73, 1.91) | 2.17 (1.34, 3.53) |
Model 2 | Ref (1.0) | 1.2 (0.76, 1.91) | 1.19 (0.73, 1.93) | 2.15 (1.33, 3.51) |
Model 3 | Ref (1.0) | 1.17 (0.73, 1.87) | 1.11 (0.67, 1.81) | 1.95 (1.15, 3.3) |
Stable | Transition to high TC | Stable | Transition to high TC | |
---|---|---|---|---|
Number of participants | 6676 | 836 | 2058 | 266 |
CAP case | 61 | 24 | 36 | 12 |
Model 1 | Ref (1.0) | 2.26 (1.39, 3.65) | 1.45 (0.95, 2.19) | 2.7 (1.45, 5.03) |
Model 2 | Ref (1.0) | 2.25 (1.38, 3.66) | 1.45 (0.96, 2.2) | 2.71 (1.46, 5.05) |
Model 3 | Ref (1.0) | 2.04 (1.22, 3.43) | 1.33 (0.87, 2.05) | 2.34 (1.21, 4.53) |
Stable | Transition to high TG | Stable | Transition to high TG | |
---|---|---|---|---|
Number of participants | 6604 | 908 | 1729 | 595 |
CAP case | 69 | 16 | 27 | 21 |
Model 1 | Ref (1.0) | 1.23 (0.71, 2.12) | 1.14 (0.73, 1.79) | 2.37 (1.44, 3.9) |
Model 2 | Ref (1.0) | 1.23 (0.72, 2.13) | 1.15 (0.74, 1.81) | 2.37 (1.44, 3.92) |
Model 3 | Ref (1.0) | 1.23 (0.69, 2.2) | 1.08 (0.68, 1.71) | 2.27 (1.30, 3.95) |
Stable | Transition to high LDL-C | Stable | Transition to high LDL-C | |
---|---|---|---|---|
Number of participants | 6248 | 1264 | 1774 | 550 |
CAP case | 51 | 34 | 31 | 17 |
Model 1 | Ref (1.0) | 2.26 (1.46, 3.5) | 1.59 (1.01, 2.49) | 2.39 (1.38, 4.16) |
Model 2 | Ref (1.0) | 2.27 (1.47, 3.51) | 1.6 (1.02, 2.51) | 2.4 (1.38, 4.17) |
Model 3 | Ref (1.0) | 1.95 (1.20, 3.17) | 1.52 (0.95, 2.42) | 2.03 (1.11, 3.73) |
Stable | Transition to low HDL-C | Stable | Transition to low HDL-C | |
---|---|---|---|---|
Number of participants | 7403 | 109 | 2252 | 72 |
CAP case | 83 | 2 | 45 | 3 |
Model 1 | Ref (1.0) | 1.68 (0.41, 6.83) | 1.37 (0.95, 1.98) | 4.55 (1.43, 14.53) |
Model 2 | Ref (1.0) | 1.65 (0.41, 6.71) | 1.37 (0.95, 1.99) | 4.51 (1.41, 14.4) |
Model 3 | Ref (1.0) | 1.61 (0.39, 6.69) | 1.27 (0.86, 1.87) | 4.62 (1.4, 15.22) |