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16.05.2024 | Original Article

Treadmill exercise promotes bone tissue recovery in rats subjected to high + Gz loads

verfasst von: Lilan Gao, Ruiqi Chen, Xianglong Lin, Jie Liu, Jin Liu, Yansong Tan, Chunqiu Zhang, Xizheng Zhang

Erschienen in: Journal of Bone and Mineral Metabolism

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Abstract

Introduction

High + Gz loads, the gravitational forces experienced by the body in hypergravity environments, can lead to bone loss in pilots and astronauts, posing significant health risks.

Materials and methods

To explore the effect of treadmill exercise on bone tissue recovery, a study was conducted on 72 male Wistar rats. These rats were subjected to four weeks of varying levels of periodic high + Gz loads (1G, 8G, 20G) experiments, and were subsequently divided into the treadmill group and the control group. The treadmill group underwent a continuous two-week treadmill experiment, while the control group rested during this period. The mechanical properties, microstructure, and molecular markers of their tibial bone tissue were measured using three-point bending, micro-CT, and PCR.

Results

The results showed that treadmill exercise improved the elastic modulus, ultimate deflection, and ultimate load of rat bone tissue. It also increased the number, density, and volume fraction of bone trabeculae, and decreased their separation. Moreover, treadmill exercise enhanced osteogenesis and inhibited osteoclastogenesis.

Conclusion

This study demonstrates that treadmill exercise can promote the recovery of bone tissue in rats subjected to high + Gz loads, providing a potential countermeasure for bone loss in pilots and astronauts.

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Titel: Treadmill exercise promotes bone tissue recovery in rats subjected to high + Gz loads
verfasst von: Lilan Gao
Ruiqi Chen
Xianglong Lin
Jie Liu
Jin Liu
Yansong Tan
Chunqiu Zhang
Xizheng Zhang
Publikationsdatum: 16.05.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-024-01513-7

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Treadmill exercise promotes bone tissue recovery in rats subjected to high + Gz loads

Abstract

Introduction

Materials and methods

Results

Conclusion

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Abstract

Introduction

Materials and methods

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Conclusion

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