Background
Methods
Study design
Setting
Data sources
Participants
Reference dataset
Case definitions
Case definition | Description |
---|---|
Case definition 1 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM code starting with 691.xx or 692.xx |
Case definition 1b | ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM code 691 or 692 |
Case definition 2 | ≥ 1 health condition for 3-digit ICD-9-CM code 691, 692 OR ≥ 2 billing/Encounter Diagnosis for 3-digit ICD-9-CM code 691, 692 |
Case definition 3 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM code starting with 691.xx or 692.xx OR ≥ 1 medication for ATC code starting with D07, D02A, D11AH |
Case definition 4 | ≥ 1 health condition for ICD-9-CM code starting with 691.xx, 692.xx OR ≥ 2 billing encounter diagnosis for ICD-9-CM starting with 691.xx, 692.xx OR ≥ 1 medication for ATC code starting with D07, D02A, D11AH |
Case definition 5 | ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM 691 |
Case definition 6 | ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM 692 |
Case definition 7 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 |
Case definition 8 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 OR ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM 691, 692 |
Case definition 9 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 OR ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM 691, 692 AND ≥ 1 medication for ATC code starting with D07, D02A, D11AH |
Case definition 10 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 OR ≥ 1 medication for ATC code starting with D07, D02A, D11AH |
Case definition 11 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 or 692.9 OR ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM 691, 692 AND ≥ 1 medication for ATC code starting with D07, D02A, D11AH |
Case definition 12 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 or 692.9 OR ≥ 1 medication for ATC code starting with D07, D02A, D11AH |
Case definition 13 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 or 692.9 |
Case definition 14 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 or 692.9 OR ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM 691 or 692 |
Case definition 15 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM code starting with 691.xx or 692.xx AND ≥ 1 health condition, billing or encounter diagnosis for atopy condition ICD-9-CM starting with 493.xx (asthma) or 472.xx/477.xx (rhinitis/hay fever) OR ≥ 1 allergy documented in the allergy table of the EMR |
Case definition 16 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM code starting with 691.xx or 692.xx AND ≥ 1 health condition, billing or encounter diagnosis for atopy condition ICD-9-CM starting with 493.xx (asthma) or 472.xx/477.xx (rhinitis/hay fever) OR ≥ 1 food allergy documented in the allergy table of the EMR |
Case definition 17 | ≥ 1 health condition for 3-digit ICD-9-CM code 691 or 692 OR ≥ 2 billing/Encounter Diagnosis for 3-digit ICD-9-CM code 691 or 692 OR ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 or 692.9 |
Case definition 18 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 or 692.9 OR ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM code starting with 691.xx or 692.xx AND ≥ 1 health condition, billing or encounter diagnosis for atopy condition ICD-9-CM starting with 493.xx (asthma) or 472.xx/477.xx (rhinitis/hay fever) OR ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM code starting with 691.xx or 692.xx AND ≥ 1 allergy documented in the allergy table of the EMR |
Case definition 19 | ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM code 691 or 692 AND ≥ 1 health condition, billing or encounter diagnosis for atopy condition ICD-9-CM starting with 493.xx (asthma), or 472.xx/477.xx (rhinitis/hay fever) OR ≥ 1 allergy documented in the allergy table of the EMR |
Case definition 20 | ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM code 691 or 692 AND ≥ 1 health condition, billing or encounter diagnosis for atopy condition ICD-9-CM starting with 493.xx (asthma), or 472.xx/477.xx (rhinitis/hay fever) OR ≥ 1 food allergy documented in the allergy table of the EMR |
Case definition 21 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 or 692.9 OR ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM code 691 or 692 AND ≥ 1 health condition, billing or encounter diagnosis for atopy condition ICD-9-CM starting with 493.xx (asthma), or 472.xx/477.xx (rhinitis/hay fever) OR ≥ 1 allergy documented in the allergy table of the EMR |
Case definition 22 | ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM code 691 or 692 AND ≥ 1 health condition, billing or encounter diagnosis for atopy condition ICD-9-CM starting with 493.xx (asthma), or 472.xx/477.xx (rhinitis/hay fever) OR ≥ 1 allergy documented in the allergy table of the EMR OR ≥ 1 medication for ATC code starting with D07, D02A, D11AH |
Case definition 23 | ≥ 1 health condition, billing or encounter diagnosis for ICD-9-CM 691.8 or 692.9 OR ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM code 691 or 692 AND ≥ 1 health condition, billing or encounter diagnosis for atopy condition ICD-9-CM starting with 493.xx (asthma), or 472.xx/477.xx (rhinitis/hay fever) OR ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM code 691 or 692 AND ≥ 1 allergy documented in the allergy table of the EMR OR ≥ 1 health condition, billing or encounter diagnosis for 3-digit ICD-9-CM code 691 or 692 AND ≥ 1 medication for ATC code starting with D07, D02A, D11AH |
Statistical analysis
Results
Case Definition | True Positive | True Negative | False Negative | False Positive | SE | SP | PPV | NPV | ACC |
---|---|---|---|---|---|---|---|---|---|
1 | 93 | 282 | 8 | 25 | 92.1 (85.0, 96.5) | 91.9 (88.2, 94.7) | 78.8 (71.8, 84.5) | 97.2 (94.8, 98.6) | 91.9 (88.8, 94.4) |
1b | 28 | 305 | 73 | 2 | 27.7 (19.3, 37.5) | 99.4 (97.7, 99.9) | 93.3 (77.3, 98.3) | 80.7 (78.7, 82.5) | 81.6 (77.5, 85.3) |
2 | 16 | 305 | 85 | 2 | 15.8 (9.3, 24.5) | 99.4 (97.7, 99.9) | 88.9 (65.2, 97.2) | 78.2 (76.7, 79.6) | 78.7 (74.4, 82.6) |
3 | 50 | 269 | 51 | 38 | 49.5 (39.4, 59.6) | 87.6 (83.4, 91.1) | 56.8 (47.9, 65.3) | 84.1 (81.2, 86.5) | 78.2 (73.9, 82.1) |
4 | 42 | 269 | 59 | 38 | 41.6 (31.9, 51.8) | 87.6 (83.4, 91.1) | 52.5 (43.1, 61.7) | 82.0 (79.4, 84.4) | 76.2 (71.8, 80.3) |
5 | 19 | 306 | 82 | 1 | 18.8 (11.7, 27.8) | 99.7 (98.2, 100) | 95.0 (72.0, 99.3) | 78.9 (77.3, 80.4) | 79.7 (75.4, 83.5) |
6 | 14 | 306 | 87 | 1 | 13.9 (7.8, 22.2) | 99.7 (98.2, 100) | 93.3 (65.1, 99.1) | 77.9 (76.5, 79.2) | 78.4 (74.1, 82.3) |
7 | 16 | 307 | 85 | 0 | 15.8 (9.3, 24.5) | 100 (98.8, 100) | 100 | 78.3 (76.9, 79.7) | 79.2 (74.9, 83.0) |
8 | 44 | 305 | 57 | 2 | 43.6 (33.7, 53.8) | 99.4 (97.7, 99.9) | 95.7 (84.5, 98.9) | 84.3 (81.8, 86.4) | 85.5 (81.8, 88.8) |
9 | 25 | 305 | 76 | 2 | 24.8 (16.7, 34.3) | 99.4 (97.7, 99.9) | 24.8 (20.6, 29.2) | 80.1 (78.2, 81.8) | 80.9 (76.7, 84.6) |
10 | 43 | 269 | 58 | 38 | 42.6 (32.8, 52.8) | 87.6 (83.4, 91.1) | 53.1 (43.8, 62.2) | 82.3 (79.6, 84.7) | 76.5 (72.1, 80.5) |
11 | 69 | 288 | 32 | 19 | 68.3 (58.3, 77.2) | 93.8 (90.5, 96.2) | 78.4 (69.7, 85.1) | 90.0 (87.1, 92.3) | 87.5 (83.9, 90.6) |
12 | 67 | 257 | 34 | 50 | 66.3 (56.3, 75.4) | 83.7 (79.1, 87.7) | 57.3 (50.1, 64.2) | 88.3 (85.1, 90.9) | 79.4 (75.2, 83.2) |
13 | 60 | 289 | 41 | 18 | 59.4 (49.2, 69.1) | 94.1 (90.9, 96.5) | 76.9 (67.4, 84.3) | 87.6 (84.8, 89.9) | 85.5 (81.8, 88.8) |
14 | 87 | 288 | 14 | 19 | 86.1 (77.8, 92.2) | 93.8 (90.5, 96.2) | 82.1 (74.6, 87.7) | 95.4 (92.7, 97.1) | 91.9 (88.8, 94.4) |
15 | 27 | 301 | 74 | 6 | 26.7 (18.4, 36.5) | 98.1 (95.8, 99.3) | 81.8 (65.7, 91.4) | 80.3 (78.3, 82.1) | 80.4 (76.2, 84.1) |
16 | 23 | 301 | 78 | 6 | 22.8 (15.0, 32.2) | 98.1 (95.8, 99.3) | 79.3 (61.6, 90.2) | 79.4 (77.6, 81.1) | 79.4 (75.2, 83.2) |
17 | 76 | 288 | 25 | 19 | 75.3 (65.7, 83.3) | 93.8 (90.5, 96.2) | 80.0 (71.8, 86.3) | 92.0 (89.1, 94.2) | 89.2 (85.8, 92.1) |
18 | 70 | 286 | 31 | 21 | 69.3 (59.3, 78.1) | 93.2 (89.7, 95.7) | 76.9 (68.4, 83.7) | 90.2 (87.3, 92.5) | 87.3 (83.6, 90.3) |
19 | 11 | 306 | 90 | 1 | 10.9 (5.6, 18.7) | 99.7 (98.2, 100) | 91.7 (59.0, 98.8) | 77.3 (76.1, 78.5) | 77.7 (73.3, 81.6) |
20 | 9 | 306 | 92 | 1 | 8.9 (4.2, 16.2) | 99.7 (98.2, 100) | 90.0 (53.6, 98.6) | 76.9 (75.8, 78.0) | 77.2 (72.8, 81.2) |
21 | 70 | 288 | 31 | 19 | 69.3 (59.3, 78.1) | 93.8 (90.5, 96.2) | 78.7 (70.1, 85.3) | 90.3 (87.4, 92.6) | 87.8 (84.2, 90.8) |
22 | 44 | 305 | 57 | 2 | 43.6 (33.7, 53.8) | 99.4 (97.7, 99.9) | 95.7 (84.5, 98.9) | 84.3 (81.8, 86.4) | 85.5 (81.8, 88.8) |
23 | 77 | 288 | 24 | 19 | 76.2 (66.7, 84.1) | 93.8 (90.5, 96.2) | 80.2 (72.1, 86.4) | 92.3 (89.4, 94.5) | 89.5 (86.1, 92.3) |
Case Definition | True Positive | True Negative | False Negative | False Positive | SE | SP | PPV | NPV | ACC |
---|---|---|---|---|---|---|---|---|---|
1 | 93 | 1234 | 8 | 161 | 92.1 (85.0, 96.5) | 88.5 (86.7, 90.1) | 36.6 (33.1, 40.3) | 99.4 (98.8, 99.7) | 88.7 (87.0, 90.3) |
1b | 28 | 1328 | 73 | 67 | 27.7 (19.3, 37.5) | 95.2 (93.9, 96.3) | 29.5 (22.0, 38.2) | 94.8 (94.2, 95.4) | 90.6 (89.1, 92.1) |
2 | 16 | 1379 | 85 | 16 | 15.8 (9.3, 24.5) | 98.9 (98.1, 99.3) | 50.0 (34.0, 66.0) | 94.2 (93.7, 94.6) | 93.3 (91.9, 94.5) |
3 | 50 | 1165 | 51 | 230 | 49.5 (39.4, 59.6) | 83.5 (81.5, 85.4) | 17.9 (14.7, 21.5) | 95.8 (95.0, 96.5) | 81.2 (79.1, 83.2) |
4 | 42 | 1190 | 59 | 205 | 41.6 (31.9, 51.8) | 85.3 (83.3, 87.1) | 17.0 (13.6, 21.1) | 95.3 (94.5, 96.0) | 82.4 (80.3, 84.3) |
5 | 19 | 1361 | 82 | 34 | 18.8 (11.7, 27.8) | 97.6 (96.6, 98.3) | 35.9 (24.9, 48.6) | 94.3 (93.8, 94.8) | 92.3 (90.8, 93.6) |
6 | 14 | 1359 | 87 | 36 | 13.9 (7.8, 22.2) | 97.4 (96.5, 98.2) | 28.0 (17.8, 41.1) | 94.0 (93.5, 94.4) | 91.8 (90.3, 93.1) |
7 | 16 | 1392 | 85 | 3 | 15.8 (9.3, 24.5) | 99.8 (99.4, 100) | 84.2 (61.2, 94.7) | 94.3 (93.8, 94.7) | 94.1 (92.8, 95.3) |
8 | 44 | 1325 | 57 | 70 | 43.6 (33.7, 53.8) | 95.1 (93.8, 96.1) | 38.6 (31.4, 46.4) | 96.0 (95.2, 96.6) | 91.7 (90.2, 93.0) |
9 | 25 | 1360 | 76 | 35 | 24.8 (16.7, 34.3) | 97.5 (96.5, 98.3) | 41.7 (30.8, 53.4) | 94.7 (94.1, 95.2) | 92.6 (91.1, 93.9) |
10 | 43 | 1197 | 58 | 198 | 42.6 (32.8, 52.8) | 85.8 (83.9, 87.6) | 17.8 (14.3, 22.0) | 95.4 (94.6, 96.1) | 82.9 (80.9, 84.8) |
11 | 69 | 1282 | 32 | 113 | 68.3 (58.3, 77.2) | 91.9 (90.3, 93.3) | 37.9 (32.9, 43.2) | 97.6 (96.8, 98.2) | 90.3 (88.7, 91.8) |
12 | 67 | 1147 | 34 | 248 | 66.3 (56.3, 75.4) | 82.2 (80.1, 84.2) | 21.3 (18.4, 24.4) | 97.1 (96.2, 97.8) | 81.2 (79.1, 83.1) |
13 | 60 | 1310 | 41 | 85 | 59.4 (49.2, 69.1) | 93.9 (92.5, 95.1) | 41.4 (35.2, 47.8) | 97.0 (96.2, 97.6) | 91.6 (90.1, 92.9) |
14 | 87 | 1249 | 14 | 146 | 86.1 (77.8, 92.2) | 89.5 (87.8, 91.1) | 37.3 (33.4, 41.5) | 99.0 (98.2, 99.3) | 89.3 (87.6, 90.8) |
15 | 27 | 1347 | 74 | 48 | 26.7 (18.4, 36.5) | 96.6 (95.5, 97.5) | 36.0 (26.9, 46.3) | 94.8 (94.2, 95.4) | 91.8 (90.3, 93.2) |
16 | 23 | 1355 | 78 | 40 | 22.8 (15.0, 32.2) | 97.1 (96.1, 97.9) | 36.5 (26.4, 48.0) | 94.6 (94.0, 95.1) | 92.1 (90.6, 93.4) |
17 | 76 | 1297 | 25 | 98 | 75.3 (65.7, 83.3) | 93.0 (91.5, 94.3) | 43.7 (38.3, 49.2) | 98.1 (97.4, 98.7) | 91.8 (90.3, 93.1) |
18 | 70 | 1283 | 31 | 112 | 69.3 (59.3, 78.1) | 92.0 (90.4, 93.3) | 38.5 (33.4, 43.8) | 97.6 (96.9, 98.2) | 90.4 (88.8, 91.9) |
19 | 11 | 1368 | 90 | 27 | 10.9 (5.6, 18.7) | 98.1 (97.2, 98.7) | 29.0 (17.2, 44.4) | 93.8 (93.4, 94.2) | 92.2 (90.7, 93.5) |
20 | 9 | 1374 | 92 | 21 | 8.9 (4.2, 16.2) | 98.5 (97.7, 99.1) | 30.0 (16.8, 47.7) | 93.7 (93.4, 94.1) | 92.5 (91.0, 93.7) |
21 | 70 | 1285 | 31 | 110 | 69.3 (59.3, 78.1) | 92.1 (90.6, 93.5) | 38.9 (33.8, 44.3) | 97.6 (96.9, 98.2) | 90.6 (89.0, 92.0) |
22 | 44 | 1325 | 57 | 70 | 43.6 (33.7, 53.8) | 95.0 (93.7, 96.1) | 38.6 (31.4, 46.4) | 95.9 (95.1, 96.5) | 91.5 (90.0, 92.9) |
23 | 77 | 1263 | 24 | 132 | 76.2 (66.7, 84.1) | 90.5 (88.9, 92.0) | 36.8 (32.4, 41.5) | 98.1 (97.4, 98.7) | 89.6 (87.9, 91.1) |
Case definition | Prevalence n(%, 95%CI) | Female patient, n(%) | Patient age, mean(SD) | Eczema medication n (%) | Patients with an allergy n (%) | Patients with asthma n(%) | Patients with rhinitis n(%) |
---|---|---|---|---|---|---|---|
Case definition 1 | 104,354 (15.1%, 15.05–15.22%) |
65,085 (62.4%)
|
53.9 (19.9)
|
27,885 (26.7%)
| 14,948 (14.3%) |
18,973 (18.2%)
|
11,151 (10.7%)
|
Case definition 7 | 5569 (0.8%, 0.79–0.83%) |
3479 (62.5%)
|
48.9 (20.3)
|
1620 (29.1%)
|
447 (8.0%)
|
1228 (22.1%)
|
786 (14.1%)
|
Case definition 13 | 28,762 (4.2%, 4.13–4.22%) |
18,240 (63.4%)
|
51.9 (20.0)
|
8452 (29.4%)
|
2892 (10.1%)
|
5426 (18.9%)
|
4208 (14.6%)
|
Case definition 14 | 97,980 (14.2%, 14.13–14.3%) |
61,258 (62.5%)
|
53.9 (19.9)
|
26,301 (26.8%)
| 14,260 (14.6%) |
17,998 (18.4%)
|
10,429 (10.6%)
|
Case definition 17 | 56,171 (8.2%, 8.08–8.21%) |
35,434 (63.1%)
|
53.4 (20.1)
|
15,275 (27.2%)
|
7504 (13.4%)
|
11,007 (19.6%)
|
7167 (12.8%)
|
Case definition 23 | 67,416 (9.8%, 9.71–9.85%) |
42,467 (63.0%)
|
52.3 (20.0)
| 26,301 (39.0%) [1] |
14,260 (21.2%)
1
|
17,998 (26.7%)
1
|
10,429 (15.5%)
1
|
Patients not captured in an eczema case definition | 584,538 (84.8%) | 322,481 (55.2%) | 52.0 (19.3) | 55,506 (9.5%) | 84,878 (14.5%) | 64,811 (11.1%) | 31,863 (5.5%) |