Introduction
Methods
Study author (year) | Study design | Level of evidence | Study methods (summarized) | Study results (concerning yawning + airway) | Temporal relationships | Possible confounding factors*** |
---|---|---|---|---|---|---|
Bartlett (1971) [38] * | RCT | 2b | 100 patients after elective surgery: Group A (n = 50) used a spirometer combined and provoked yawning (at least 10 per hour). Group B (n = 50) control group | Intervention decreases postoperative pulmonary complications (e.g., atelectasis) from 30% (group B) to 10% (group A). Pulmonary complications reduced significantly | ↑ Yawns ⥬ ↓ Obstructive airway (↓ Yawns ⥬ ↑ Obstructive airway) | Spirometer |
Evans (1978) [39] | Case report | 5b | 2 case reports of chocking children in emergency setting with increased yawning | Increased yawning while choking; decreased yawning after the obstruction was relieved Yawning might be stimulated by vagal feedback arising from the pharynx | ↑ Obstructive airway ⥬ ↑ Yawns ↓ Obstructive airway ⥬ ↓ Yawns | |
Mukai (1991) [40] | Case series | 4a | 51 patients (age 3–59 weeks) with ankyloglossia were examined: O2 measurements, fibroscopic examination of epiglottal, and laryngeal deviation. Frenotomy and correction of tongue, epiglottis, and larynx if necessary | More frequent yawning in epiglottal and laryngeal deviation and when O2 levels dropped | ↑ Obstructive airway ⥬ ↑ Yawns | Ankyloglossia sleepiness |
Kim (2002) [41] | Randomized observational clinical study | 2a | 60 healthy adult patients were induced in anesthesia with thiopental (n = 30) and propofol (n = 30) and all patients were observed (verbal response, eye-lash reflex yawning, apnea) before intubation | During induction, 83% of thiopental patients and 63% of propofol patients yawned before intubation | ↑ Obstructive airway ⥬ ↑ Yawns | Propofol, thiopental, sleepiness |
Kasuya (2005) [42] | Prospective cohort | 2a | 60 patients ASA 1 / 2 undergoing elective surgery induced thiopental and propofol, together with atropine and hydroxyzine hydrochloride | During induction 60% of thiopental patients and 47% propofol patients yawned | ↑ Obstructive airway ⥬ ↑ Yawns | Propofol, thiopental, sleepiness |
Oshima (2007) [43] | Retrospective cohort | 3a | 1322 patients undergoing elective surgery, thiopental, yawning response in 461. Inhibited yawning response by thiopental + fentanyl (n = ~ 450), female sex, clonidine | During induction, around 50% of thiopental-induced patients (not treated with fentanyl) yawned | ↑ Obstructive airway ⥬ ↑ Yawns | Propofol, thiopental, sleepiness |
Tsou (2008) [44] | Prospective cohort | 2a | 546 ASA 1 / 2 patients undergoing elective surgery, induced with propofol only (n = 386), propofol with atropine (n = 90), and propofol with fentanyl (n = 50) | During induction, yawning occurred in 54% (propofol), 61% (propofol + atropine), and 0% (propofol + fentanyl) | ↑ Obstructive airway ⥬ ↑ Yawns | Propofol, sleepiness |
Oshima (2010) [45] | RCT | 2a | 180 ASA 1/2 patients undergoing elective surgery with thiopental induction combined with landiolol (n = 60), nicardipine (n = 60), and saline (n = 60) | During induction, yawning occurred in 7% (thiopental + landiolol), 17% (thiopental + nicardipine), and 47% (thiopental + saline) | ↑ Obstructive airway ⥬ ↑ Yawns | Thiopental, landiolol, nicardipine, saline sleepiness |
Gallup, Gallup (2010) [46] | Case report | 5b | 2 case reports of excessive yawning | One case with sleep apnea | ↑ Obstructive airway ⥬ ↑ Yawns | Sleepiness |
Carra (2011) [47] | Cross-sectional study | 3a | 604 patients (7-17 years old) seeking orthodontic treatment | Teeth clenching is accompanied by significant difficulties of yawning in this group (tabel 3.3.3), together with snoring/OSA-like symptoms | ↓ Yawns ⥬ ↑ Obstructive airway | Teeth clenching, OSA, sleepiness |
Tsou (2012) * [48] | Prospective cohort | 2a | 82 ASA 1 / 2 patients undergoing elective surgery with propofol induction and cardiovascular and cardio-respiratory interaction was measured | During induction with propofol, yawning occurred in 65% | ↑ Obstructive airway ⥬ ↑ Yawns | Propofol, sleepiness |
Zaharna (2013) [49] | Case report | 5a | One patient presented with sleepiness and yawning, diagnosed with OSA syndrome and improved with CPAP | Increased yawning in OSA syndrome | ↑ Obstructive airway ⥬ ↑ Yawns | OSA, sleepiness |
Catli (2015) [ 50] | Prospective cohort | 2a | 129 patients with suspected OSA syndrome were monitored during sleep and their yawns were counted during the day, divided in 2 groups: AHI < 5 (n = 43), and AHI > 30 (n = 86), and were compared with parameters (1) duration of sleep phases, (2) oxygen saturations, (3) sleep efficacies, (4) yawning frequencies, and (5) Epworth scores | Increased AHI index and lower sO2 during sleep led to increased yawning during day. Group 1 (AHI 22, sO2 94%) 4–5 times/day, Group 2 (AHI 87, sO2 92%) 10–11 times/day | ↑ Obstructive airway ⥬ ↑ Yawns ↓ Obstructive airway ⥬ ↓ Yawns | Sleepiness Thinking of yawning |