Gliomas are the most common primary intracranial tumors, accounting for more than 80% of malignant brain tumors. These tumors are highly diverse, and their prognosis varies widely: overall survival for patients with pilocytic astrocytoma can be …
verfasst von:
Malte Ottenhausen, Mirjam Renovanz, Isabell Bartz, Alicia Poplawski, Darius Kalasauskas, Harald Krenzlin, Naureen Keric, Florian Ringel
5-aminolevulinic acid (5-ALA) is a clinical fluorescence agent first introduced in neurosurgery as an adjuvant tool for malignant glioma resection in 1998 [ 41 ]. It is a natural precursor of hemoglobin in human cells that, when taken orally …
verfasst von:
Erasmo Barros da Silva Jr, Ricardo Ramina, Jorge Luis Novak Filho, Gustavo Simiano Jung, Giulia Xavier Bornancin, Maurício Coelho Neto
Gliomatosis cerebri (GC) is defined as a diffuse glioma that exhibits an infiltrative growth pattern affecting at least three lobes of the brain while grossly maintaining the underlying normal brain architecture [ 1 , 2 ]. Initially recognized as a …
verfasst von:
Ilah Shin, Yongsik Sim, Seo Hee Choi, Yae Won Park, Narae Lee, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Glioblastoma (GBM; World Health Organization (WHO) Grade IV) is the most common and aggressive primary brain tumour in adults, accounting for about 15% of all primary brain tumours and roughly 48% of all malignant gliomas [ 1 , 2 ]. Most cases of …
verfasst von:
Wafa Baqri, Kathryn Rzadki, Steven Habbous, Sunit Das
Neurooncology is a rapidly evolving field, with advances in surgical techniques, radiation therapy, and systemic therapy resulting in improved outcomes for patients with brain tumors. Despite these encouraging strides, the management of malignant …
verfasst von:
Anna Cecilia Lawson McLean, Aaron Lawson McLean, Thomas Ernst, Marie-Therese Forster, Christian Freyschlag, Jens Gempt, Roland Goldbrunner, Stefan Grau, Christine Jungk, Birgitt van Oorschot, Steffen K. Rosahl, Ulrich Wedding, Christian Senft, Marcel A. Kamp, on behalf of the German Consortium for Excellence in Neurooncology, Palliative Care (GCE-NPC)
Brain metastases develop in roughly 10–30% of adult cancer patients, and represent a major cause of morbidity and mortality [ 1 – 3 ]. Stereotactic radiosurgery (SRS) has emerged as the treatment of choice for patients with limited brain metastases …
verfasst von:
Mustafa M. Basree, Chengnan Li, Hyemin Um, Anthony H. Bui, Manlu Liu, Azam Ahmed, Pallavi Tiwari, Alan B. McMillan, Andrew M. Baschnagel
Glioblastoma (GBM), the most common malignant primary brain tumor, is uniformly fatal despite conventional therapy with surgery, radiation, and chemotherapy. One of the difficulties in treating GBM stems from the intrinsic privileged nature of the …
verfasst von:
Omer Doron, Tamika Wong, Faina Ablyazova, Souvik Singha, Julianna Cavallaro, Netanel Ben-Shalom, Randy S. D’Amico, Manju Harshan, Amy McKeown, Avraham Zlochower, David J. Langer, John A. Boockvar
Glioblastoma (GBM) is the most common adult central nervous system malignancy [ 1 ]. GBM has an overall poor prognosis, which is reduced further by advanced age, frailty, and incomplete extent of surgical resection [ 2 ]. The landmark Stupp et al.
verfasst von:
Megan Parker, Foad Kazemi, A. Karim Ahmed, Cathleen C. Kuo, Sumil K. Nair, Jordina Rincon-Torroella, Christopher Jackson, Gary Gallia, Chetan Bettegowda, Jon Weingart, Henry Brem, Debraj Mukherjee
Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma that accounts for 3–5% of all primary intracranial tumors [ 1 , 2 ]. Whole-brain radiotherapy (WBRT) alone for PCNSL results in overall survival (OS) …
Intracranial meningiomas often recur even after gross total resection with and without adjuvant radiation treatment, with a rate ranging from 10 to 32% at 10 years [ 1 , 2 ]. The main risk factors include the WHO grade [ 3 – 5 ], the proliferation …
verfasst von:
Francesco Maiuri, Sergio Corvino, Giuseppe Corazzelli, Marialaura Del Basso De Caro
The incidence of spinal metastases (SM) is reported to be around 16% in solid tumors and result in meaningful impairment of quality of life (QOL) due to pain or neurological deficits [ 1 – 4 ]. The current treatment of SM involves spinal surgery …
verfasst von:
P. Krauss, C. L. Wolfert, B. Sommer, B. Stemmer, G. Stueben, K. H. Kahl, E. Shiban
The Glioblastoma Multiforme (GBM) is a mainly intracranial tumor with an extremely unfavorable prognosis. The current standard treatments for GBM include aggressive surgical operation intervention, radiotherapy and adjuvant chemotherapy. Although …
verfasst von:
Ting Sun, Bin Liu, Lize Cai, Youxin Zhou, Wei Yang, Yanyan Li
Von Hippel-Lindau (VHL) disease is a syndrome of familial predisposition to the development of various malignant and benign tumors caused by inactivation of the VHL tumor suppressor gene [ 1 – 4 ]. Central nervous system (CNS) hemangioblastomas are …
verfasst von:
Anna Laura Knoblauch, B.-I. Blaß, C. Steiert, N. Neidert, A. Puzik, E. Neumann-Haefelin, A. Ganner, F. Kotsis, T. Schäfer, H.P.H. Neumann, S. Elsheikh, J. Beck, J.-H. Klingler
In the rapidly evolving landscape of clinical oncology, significant advancements have been made in the treatment of brain metastases, shifting from traditional whole-brain radiotherapy (WBRT) towards more targeted and localized approaches such as …
Central nervous system embryonal tumors (CNS-ETs) are highly aggressive, poorly differentiated malignancies occurring predominantly in young children but also affecting adolescents and adults. While historically categorized uniformly based on …
verfasst von:
Kevin J. Bielamowicz, Mary Beth Littrell, Gregory W. Albert, Lora S. Parker, Sateesh Jayappa, Kenneth Aldape, Murat Gokden
Glioblastoma (GBM) is the most aggressive glioma recurring on a regular basis despite extensive tumor treatment and usually resulting into a limited overall survival (OS) [ 1 ]. Although GBM is a clearly defined entity on a histological and …
verfasst von:
Katharina Conrad, Ronja Löber-Handwerker, Mohammad Hazaymeh, Veit Rohde, Vesna Malinova
Diffuse midline gliomas (DMGs) are rare central nervous system (CNS) tumors that primarily affect pediatric patients, are typically fatal within a year of diagnosis, and have yet to be effectively treated [ 1 , 2 ]. DMGs that occur in adults are …
verfasst von:
Jay Desai, Sujay Rajkumar, Matthew J. Shepard, John Herbst, Stephen M. Karlovits, Shakir Hasan, Zachary D. Horne, Rodney E. Wegner
Glioblastoma is the most common and most aggressive primary brain tumour in adults, with incidence increasing with age [ 1 ]. The median age at diagnosis is 65–67 years [ 1 ], however, in clinical trials the median age of enrolled patients is much …
verfasst von:
Lucy Gately, C. Mesía, J. M. Sepúlveda, S. del Barco, E. Pineda, R. Gironés, J. Fuster, M. Dumas, S. Gill, L. M. Navarro, A. Herrero, A. Dowling, R. de las Peñas, M. A. Vaz, M. Alonso, Z. Lwin, R. Harrup, S. Peralta, A. Long, P. Perez-Segura, E. Ahern, C. O. Garate, M. Wong, R. Campbell, K. Cuff, R. Jennens, O. Gallego, C. Underhill, M. Martinez-Garcia, M. Covela, A. Cooper, S. Brown, M. Rosenthal, J. Torres, I. M. Collins, P. Gibbs, C. Balana
Meningiomas are the most common primary brain and central nervous system tumors, accounting for approximately 40% of these tumors [ 1 ]. Meningiomas are slow-growing neoplasms thought to arise from meningothelial cells found within arachnoid …
verfasst von:
Arthur Araújo Massoud Salame, Helaine Laiz Silva Charchar, José Paulo de Oliveira Dourado, Berenice Mendonca, Guilherme Asmar Alencar, Leonardo José Tadeu de Araújo, Paula Ricci Arantes, Nicollas Nunes Rabelo, Eberval Gadelha Figueiredo, Maria Candida Barisson Villares Fragoso
