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06.12.2023 | Original Article

Can TBS reference values be a valid indicator for clinical vertebral fracture? A cross-sectional study

verfasst von: Yasuyuki Omichi, Noriaki Mima, Keizo Wada, Ryo Okada, Yasuaki Tamaki, Daisuke Hamada, Tomohiro Goto, Masatoshi Morimoto, Tsutomu Enomoto, Hiroki Hayashi, Koichi Sairyo

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 1/2024

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Abstract

Introduction

Trabecular bone score (TBS) is partially independent of fracture risk. Reference values for TBS have not been established in official guidelines, and thus clinicians often have difficulty interpreting TBS results. This study aimed to investigate whether reference values for TBS could be a valid indicator for clinical vertebral fracture (CVF).

Materials and methods

This cross-sectional study involved 231 women with CVF and 563 women without CVF aged 60–90 years who underwent dual-energy X-ray absorptiometry during 2019–2023. They were divided into osteoporosis, osteopenia, and normal groups according to bone mineral density of the lumbar spine. Reference values for TBS were defined as low (≤ 1.23), intermediate (1.23–1.31), and high (≥ 1.31).

Results

Among patients without anti-osteoporosis treatment (n = 476), the proportion with low TBS was 36.7% in the CVF group and 10.7% in the control group. The proportion with CVF was higher in the low TBS group than in the intermediate and high TBS groups, especially in the osteoporosis group (p < 0.001). The odds ratio for CVF was higher in the low TBS group than in the intermediate and high especially in patients with normal BMD and osteoporosis. The TBS cut-off values for incidence of CVF in the osteoporosis, osteopenia, and normal groups were 1.224, 1.319, and 1.322, respectively.

Conclusions

The reference value for low TBS (≤ 1.23) was useful as an indicator for CVF, especially in patients with osteoporosis. It is expected that reference values for TBS will be established in official guidelines in the future.

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Titel: Can TBS reference values be a valid indicator for clinical vertebral fracture? A cross-sectional study
verfasst von: Yasuyuki Omichi
Noriaki Mima
Keizo Wada
Ryo Okada
Yasuaki Tamaki
Daisuke Hamada
Tomohiro Goto
Masatoshi Morimoto
Tsutomu Enomoto
Hiroki Hayashi
Koichi Sairyo
Publikationsdatum: 06.12.2023
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 1/2024
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-023-01476-1

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Can TBS reference values be a valid indicator for clinical vertebral fracture? A cross-sectional study