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Lasers in Medical Science

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01.12.2024 | Original Article

Characterizing colon cancer stages through optical polarimetry-assisted digital staining

verfasst von: Mahima Sharma, Sujatha Narayanan Unni, Chitra Shaji, Subalakshmi Balasubramanian, Sandhya Sundaram

Erschienen in: Lasers in Medical Science | Ausgabe 1/2024

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Abstract

Tissue polarimetry has been gaining importance in extracting useful diagnostic information from the structural attributes of tissues, which vary in response to the tissue health status and hence find great potential in cancer diagnosis. However, the complexities associated with cancer make it challenging to isolate the characteristic changes as the tumor progresses using polarimetry. This study attempts to experimentally characterize the polarimetric behavior in colon cancer associated with various stages of development. Bulk and unstained sections of normal and tumor colon tissue were imaged in the reflection and transmission polarimetry configurations at low and high imaging resolutions using an in-house developed Mueller polarimeter. Through this study, we observed that the information about the major contributors of scattering in colon tissue, manifesting in depolarization and retardance, can be obtained from the bulk tissue and unstained sections. These parameters aid in characterizing the polarimetric changes as the colon tumor progresses. While the unstained colon section best indicated the depolarization contrast between normal and tumor, the contrast through the retardance parameter was more pronounced in the bulk colon tissue. The results suggest that the polarimetric “digitally stained” images obtained by Mueller polarimetry are comparable with the bulk tissue counterparts, making it useful for characterizing colon cancer tissues across different stages of development.

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Titel: Characterizing colon cancer stages through optical polarimetry-assisted digital staining
verfasst von: Mahima Sharma
Sujatha Narayanan Unni
Chitra Shaji
Subalakshmi Balasubramanian
Sandhya Sundaram
Publikationsdatum: 01.12.2024
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2024
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-024-04006-1

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Characterizing colon cancer stages through optical polarimetry-assisted digital staining

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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