Skip to main content
Erschienen in: Oral Radiology 2/2022

02.07.2021 | Original Article

Fractal properties and radiomorphometric indices of the trabecular structure of the mandible in patients using systemic glucocorticoids

verfasst von: Nihal Ersu, Rıdvan Akyol, Meryem Etöz

Erschienen in: Oral Radiology | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Abstract

Objectives

The aim of this study is to evaluate the mandibular trabecular and cortical bone structure of patients using systemic glucocorticoid (GC) and compare to control group with the fractal analysis (FA) and radiomorphometric indices.

Methods

Two researchers retrospectively investigated 192 dental panoramic radiographs to compare individuals using systemic GCs to healthy controls. FA was performed in 4 different regions; geometrical center of the mandibular ramus (ROI1), cancellous bone on supracortical mandibular angle area inferior to the mandibular canal (ROI2), cancellous bone on mesial to the mental foramen (ROI3), basal cortical bone extending mental foramen to the first molars’ distal root in the mandibular corpus (ROI4). Panoramic mandibular index (PMI), mandibular cortical width (MCW) and mandibular cortical index (MCI) were performed for evaluate cortical thickness and porosity. The Shapiro–Wilk test was used to determine the normal distribution of the data, the independent t test for comparison of values and the chi-square test for descriptive statistics.

Results

There were statistically significant differences in ROI4 and MCW. The fractal dimension (FD) values in ROI4 and MCW were significantly lower in study group. There were no significant differences in FD values in ROI1, ROI2, ROI3 and PMI and MCI measurements between both groups.

Conclusions

FA and radiomorphometric measurements is an efficient method to detect early changes in bone mass. In our study, ROI4 and MCW were significantly lower in study group. Osteoporosis prevention should be considered in patients using systemic GCs.
Literatur
1.
Zurück zum Zitat Buttgereit F. Views on glucocorticoid therapy in rheumatology: the age of convergence. Nat Rev Rheumatol. 2020;16(4):239–46.PubMedCrossRef Buttgereit F. Views on glucocorticoid therapy in rheumatology: the age of convergence. Nat Rev Rheumatol. 2020;16(4):239–46.PubMedCrossRef
2.
3.
Zurück zum Zitat Canalis E, Mazziotti G, Giustina A, Bilezikian JP. Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int. 2007;18(10):1319–28.PubMedCrossRef Canalis E, Mazziotti G, Giustina A, Bilezikian JP. Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int. 2007;18(10):1319–28.PubMedCrossRef
4.
Zurück zum Zitat Briot K. Bone and glucocorticoids. Ann Endocrinol. 2018;79(3):115–8.CrossRef Briot K. Bone and glucocorticoids. Ann Endocrinol. 2018;79(3):115–8.CrossRef
5.
6.
Zurück zum Zitat Johnson RB, Gilbert JA, Cooper RC, Dai X, Newton BI, Tracy RR, et al. Alveolar bone loss one year following ovariectomy in sheep. J Periodontol. 1997;68(9):864–71.PubMedCrossRef Johnson RB, Gilbert JA, Cooper RC, Dai X, Newton BI, Tracy RR, et al. Alveolar bone loss one year following ovariectomy in sheep. J Periodontol. 1997;68(9):864–71.PubMedCrossRef
7.
Zurück zum Zitat Schulz MC, Kowald J, Estenfelder S, Jung R, Kuhlisch E, Eckelt U, et al. Site-specific variations in bone mineral density under systemic conditions inducing osteoporosis in minipigs. Front Physiol. 2017;8:426.PubMedPubMedCentralCrossRef Schulz MC, Kowald J, Estenfelder S, Jung R, Kuhlisch E, Eckelt U, et al. Site-specific variations in bone mineral density under systemic conditions inducing osteoporosis in minipigs. Front Physiol. 2017;8:426.PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Johnson RB, Gilbert JA, Cooper RC, Parsell DE, Stewart BA, Dai X, et al. Effect of estrogen deficiency on skeletal and alveolar bone density in sheep. J Periodontol. 2002;73(4):383–91.PubMedCrossRef Johnson RB, Gilbert JA, Cooper RC, Parsell DE, Stewart BA, Dai X, et al. Effect of estrogen deficiency on skeletal and alveolar bone density in sheep. J Periodontol. 2002;73(4):383–91.PubMedCrossRef
9.
Zurück zum Zitat Morin C, Fardet L. Systemic glucocorticoid therapy: risk factors for reported adverse events and beliefs about the drug. A cross-sectional online survey of 820 patients. Clin Rheumatol. 2015;34(12):2119–26.PubMedCrossRef Morin C, Fardet L. Systemic glucocorticoid therapy: risk factors for reported adverse events and beliefs about the drug. A cross-sectional online survey of 820 patients. Clin Rheumatol. 2015;34(12):2119–26.PubMedCrossRef
10.
Zurück zum Zitat Genco RJ, Borgnakke WS. Risk factors for periodontal disease. Periodontol 2000. 2013;62(1):59–94.PubMedCrossRef Genco RJ, Borgnakke WS. Risk factors for periodontal disease. Periodontol 2000. 2013;62(1):59–94.PubMedCrossRef
11.
Zurück zum Zitat Borrell LN, Papapanou PN. Analytical epidemiology of periodontitis. J Clin Periodontol. 2005;32(6):132–58.PubMedCrossRef Borrell LN, Papapanou PN. Analytical epidemiology of periodontitis. J Clin Periodontol. 2005;32(6):132–58.PubMedCrossRef
12.
Zurück zum Zitat Jolley L, Majumdar S, Kapila S. Technical factors in fractal analysis of periapical radiographs. Dentomaxillofac Radiol. 2006;35(6):393–7.PubMedCrossRef Jolley L, Majumdar S, Kapila S. Technical factors in fractal analysis of periapical radiographs. Dentomaxillofac Radiol. 2006;35(6):393–7.PubMedCrossRef
13.
Zurück zum Zitat White SC, Rudolph DJ. Alterations of the trabecular pattern of the jaws in patients with osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(5):628–35.PubMedCrossRef White SC, Rudolph DJ. Alterations of the trabecular pattern of the jaws in patients with osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(5):628–35.PubMedCrossRef
14.
Zurück zum Zitat Hwang JJ, Lee J-H, Han S-S, Kim YH, Jeong H-G, Choi YJ, et al. Strut analysis for osteoporosis detection model using dental panoramic radiography. Dentomaxillofac Radiol. 2017;46(7):20170006.PubMedPubMedCentralCrossRef Hwang JJ, Lee J-H, Han S-S, Kim YH, Jeong H-G, Choi YJ, et al. Strut analysis for osteoporosis detection model using dental panoramic radiography. Dentomaxillofac Radiol. 2017;46(7):20170006.PubMedPubMedCentralCrossRef
15.
Zurück zum Zitat Gulsahi A, Yüzügüllü B, Imirzalioglu P, Genç Y. Assessment of panoramic radiomorphometric indices in Turkish patients of different age groups, gender and dental status. Dentomaxillofac Radiol. 2008;37(5):288–92.PubMedCrossRef Gulsahi A, Yüzügüllü B, Imirzalioglu P, Genç Y. Assessment of panoramic radiomorphometric indices in Turkish patients of different age groups, gender and dental status. Dentomaxillofac Radiol. 2008;37(5):288–92.PubMedCrossRef
16.
Zurück zum Zitat Mansour S, AlGhamdi AST, Javed F, Marzouk H, Khan EA. Panoramic radiomorphometric indices as reliable parameters in predicting osteoporosis. Am J Med Sci. 2013;346(6):473–8.PubMedCrossRef Mansour S, AlGhamdi AST, Javed F, Marzouk H, Khan EA. Panoramic radiomorphometric indices as reliable parameters in predicting osteoporosis. Am J Med Sci. 2013;346(6):473–8.PubMedCrossRef
17.
Zurück zum Zitat Bajoria AA, Asha M, Kamath G, Babshet M, Patil P, Sukhija P. Evaluation of radiomorphometric indices in panoramic radiograph–a screening tool. Open Dent J. 2015;9:303–10.PubMedPubMedCentralCrossRef Bajoria AA, Asha M, Kamath G, Babshet M, Patil P, Sukhija P. Evaluation of radiomorphometric indices in panoramic radiograph–a screening tool. Open Dent J. 2015;9:303–10.PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat GöllerBulut D, Bayrak S, Uyeturk U, Ankarali H. Mandibular indexes and fractal properties on the panoramic radiographs of the patients using aromatase inhibitors. Br J Radiol. 2018;91(1091):20180442.CrossRef GöllerBulut D, Bayrak S, Uyeturk U, Ankarali H. Mandibular indexes and fractal properties on the panoramic radiographs of the patients using aromatase inhibitors. Br J Radiol. 2018;91(1091):20180442.CrossRef
19.
Zurück zum Zitat Klemetti E, Kolmakov S, Kröger H. Pantomography in assessment of the osteoporosis risk group. Eur J Oral Sci. 1994;102(1):68–72.CrossRef Klemetti E, Kolmakov S, Kröger H. Pantomography in assessment of the osteoporosis risk group. Eur J Oral Sci. 1994;102(1):68–72.CrossRef
20.
Zurück zum Zitat Cohen LH. Measurement of life events. Life events and psychological functioning: Theoretical and methodological issue. London: Sage; 1988. p. 11–30. Cohen LH. Measurement of life events. Life events and psychological functioning: Theoretical and methodological issue. London: Sage; 1988. p. 11–30.
21.
Zurück zum Zitat Evans JD. Straightforward statistics for the behavioral sciences. Pacific Grove: Thomson Brooks/Cole Publishing Co; 1996. Evans JD. Straightforward statistics for the behavioral sciences. Pacific Grove: Thomson Brooks/Cole Publishing Co; 1996.
22.
Zurück zum Zitat Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.CrossRef Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.CrossRef
23.
Zurück zum Zitat Gumussoy I, Miloglu O, Cankaya E, Bayrakdar IS. Fractal properties of the trabecular pattern of the mandible in chronic renal failure. Dentomaxillofac Radiol. 2016;45(5):20150389.PubMedPubMedCentralCrossRef Gumussoy I, Miloglu O, Cankaya E, Bayrakdar IS. Fractal properties of the trabecular pattern of the mandible in chronic renal failure. Dentomaxillofac Radiol. 2016;45(5):20150389.PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Avsever I, Orhan K, Özen T, Karaçaylı Ü, Görgülü S. Evaluation of mandibular bone structure in sickle cell anemia patients. Gulhane Med J. 2015;57:11–5.CrossRef Avsever I, Orhan K, Özen T, Karaçaylı Ü, Görgülü S. Evaluation of mandibular bone structure in sickle cell anemia patients. Gulhane Med J. 2015;57:11–5.CrossRef
25.
Zurück zum Zitat Demirbaş AK, Ergün S, Güneri P, Aktener BO, Boyacıoğlu H. Mandibular bone changes in sickle cell anemia: fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(1):e41–8.PubMedCrossRef Demirbaş AK, Ergün S, Güneri P, Aktener BO, Boyacıoğlu H. Mandibular bone changes in sickle cell anemia: fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(1):e41–8.PubMedCrossRef
26.
Zurück zum Zitat Sindeaux R, de Souza Figueiredo PT, de Melo NS, Guimarães ATB, Lazarte L, Pereira FB, et al. Fractal dimension and mandibular cortical in normal and osteoporotic men and women. Maturitas. 2014;77(2):142–8.PubMedCrossRef Sindeaux R, de Souza Figueiredo PT, de Melo NS, Guimarães ATB, Lazarte L, Pereira FB, et al. Fractal dimension and mandibular cortical in normal and osteoporotic men and women. Maturitas. 2014;77(2):142–8.PubMedCrossRef
27.
Zurück zum Zitat Southard TE, Southard KA, Krizan KE, Hillis SL, Haller JW, Keller J, et al. Mandibular bone density and fractal dimension in rabbits with induced osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(2):244–9.PubMedCrossRef Southard TE, Southard KA, Krizan KE, Hillis SL, Haller JW, Keller J, et al. Mandibular bone density and fractal dimension in rabbits with induced osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(2):244–9.PubMedCrossRef
28.
Zurück zum Zitat Kozai Y, Kawamata R, Sakurai T, Kanno M, Kashima I. Influence of prednisolone-induced osteoporosis on bone mass and bone quality of the mandible in rats. Dentomaxillofac Radiol. 2009;38(1):34–41.PubMedCrossRef Kozai Y, Kawamata R, Sakurai T, Kanno M, Kashima I. Influence of prednisolone-induced osteoporosis on bone mass and bone quality of the mandible in rats. Dentomaxillofac Radiol. 2009;38(1):34–41.PubMedCrossRef
29.
Zurück zum Zitat Belgin CA, Serindere G. Fractal and radiomorphometric analysis of mandibular bone changes in patients undergoing intravenous corticosteroid therapy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;130(1):110–5.CrossRef Belgin CA, Serindere G. Fractal and radiomorphometric analysis of mandibular bone changes in patients undergoing intravenous corticosteroid therapy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;130(1):110–5.CrossRef
30.
Zurück zum Zitat Lespessailles E, Siroux V, Poupon S, Andriambelosoa N, Pothuaud L, Harba R, et al. Long-term corticosteroid therapy induces mild changes in trabecular bone texture. J Bone Miner Res. 2000;15(4):747–53.PubMedCrossRef Lespessailles E, Siroux V, Poupon S, Andriambelosoa N, Pothuaud L, Harba R, et al. Long-term corticosteroid therapy induces mild changes in trabecular bone texture. J Bone Miner Res. 2000;15(4):747–53.PubMedCrossRef
31.
Zurück zum Zitat Adinoff AD, Hollister JR. Steroid-induced fractures and bone loss in patients with asthma. N Engl J Med. 1983;309(5):265–8.PubMedCrossRef Adinoff AD, Hollister JR. Steroid-induced fractures and bone loss in patients with asthma. N Engl J Med. 1983;309(5):265–8.PubMedCrossRef
32.
Zurück zum Zitat Reid IR, Evans MC, Stapleton J. Lateral spine densitometry is a more sensitive indicator of glucocorticoid- induced bone loss. J Bone Miner Res. 1992;7(10):1221–5.PubMedCrossRef Reid IR, Evans MC, Stapleton J. Lateral spine densitometry is a more sensitive indicator of glucocorticoid- induced bone loss. J Bone Miner Res. 1992;7(10):1221–5.PubMedCrossRef
33.
34.
Zurück zum Zitat Secgin CK, Kulah CK, Gulsahi A. Analysis of mandibular changes using panoramic-based indices in patients with chronic renal failure. Int J Artif Organs. 2018;41(1):11–6.CrossRef Secgin CK, Kulah CK, Gulsahi A. Analysis of mandibular changes using panoramic-based indices in patients with chronic renal failure. Int J Artif Organs. 2018;41(1):11–6.CrossRef
35.
Zurück zum Zitat Bayrak S, Bulut DG, Orhan K, Sinanoğlu EA, Çakmak EŞK, Mısırlı M, et al. Evaluation of osseous changes in dental panoramic radiography of thalassemia patients using mandibular indexes and fractal size analysis. Oral Radiol. 2020;36(1):18–24.PubMedCrossRef Bayrak S, Bulut DG, Orhan K, Sinanoğlu EA, Çakmak EŞK, Mısırlı M, et al. Evaluation of osseous changes in dental panoramic radiography of thalassemia patients using mandibular indexes and fractal size analysis. Oral Radiol. 2020;36(1):18–24.PubMedCrossRef
36.
Zurück zum Zitat Ledgerton D, Horner K, Devlin H, Worthington H. Radiomorphometric indices of the mandible in a British female population. Dentomaxillofac Radiol. 1999;28(3):173–81.PubMedCrossRef Ledgerton D, Horner K, Devlin H, Worthington H. Radiomorphometric indices of the mandible in a British female population. Dentomaxillofac Radiol. 1999;28(3):173–81.PubMedCrossRef
37.
Zurück zum Zitat Devlin H, Horner K. Diagnosis of osteoporosis in oral health care. J Oral Rehabil. 2008;35(2):152–7.PubMed Devlin H, Horner K. Diagnosis of osteoporosis in oral health care. J Oral Rehabil. 2008;35(2):152–7.PubMed
39.
Zurück zum Zitat Nomura Y, Watanabe H, Honda E, Kurabayashi T. Reliability of voxel values from cone-beam computed tomography for dental use in evaluating bone mineral density. Clin Oral Implants Res. 2010;21(5):558–62.PubMedCrossRef Nomura Y, Watanabe H, Honda E, Kurabayashi T. Reliability of voxel values from cone-beam computed tomography for dental use in evaluating bone mineral density. Clin Oral Implants Res. 2010;21(5):558–62.PubMedCrossRef
40.
Zurück zum Zitat Hua Y, Nackaerts O, Duyck J, Maes F, Jacobs R. Bone quality assessment based on cone beam computed tomography imaging. Clin Oral Implants Res. 2009;20(8):767–71.PubMedCrossRef Hua Y, Nackaerts O, Duyck J, Maes F, Jacobs R. Bone quality assessment based on cone beam computed tomography imaging. Clin Oral Implants Res. 2009;20(8):767–71.PubMedCrossRef
41.
Zurück zum Zitat Katsumata A, Hirukawa A, Noujeim M, Okumura S, Naitoh M, Fujishita M, et al. Image artifact in dental cone-beam CT. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(5):652–7.PubMedCrossRef Katsumata A, Hirukawa A, Noujeim M, Okumura S, Naitoh M, Fujishita M, et al. Image artifact in dental cone-beam CT. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(5):652–7.PubMedCrossRef
42.
Zurück zum Zitat Lee S, Gantes B, Riggs M, Crigger M. Bone density assessments of dental implant sites: 3. Bone quality evaluation during osteotomy and implant placement. Int J Oral Maxillofac Implants. 2007;22(2):208–12.PubMed Lee S, Gantes B, Riggs M, Crigger M. Bone density assessments of dental implant sites: 3. Bone quality evaluation during osteotomy and implant placement. Int J Oral Maxillofac Implants. 2007;22(2):208–12.PubMed
Metadaten
Titel
Fractal properties and radiomorphometric indices of the trabecular structure of the mandible in patients using systemic glucocorticoids
verfasst von
Nihal Ersu
Rıdvan Akyol
Meryem Etöz
Publikationsdatum
02.07.2021
Verlag
Springer Singapore
Erschienen in
Oral Radiology / Ausgabe 2/2022
Print ISSN: 0911-6028
Elektronische ISSN: 1613-9674
DOI
https://doi.org/10.1007/s11282-021-00552-4

Weitere Artikel der Ausgabe 2/2022

Oral Radiology 2/2022 Zur Ausgabe

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Update Zahnmedizin

Bestellen Sie unseren kostenlosen Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.