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07.02.2024 | Myocardial Disease (A Abbate and M Merlo, Section Editors)

Fulminant Myocarditis Temporally Associated with COVID-19 Vaccination

verfasst von: Enrico Ammirati, Nicolina Conti, Matteo Palazzini, Matteo Rocchetti, Andrea Spangaro, Andrea Garascia, Laura Lupi, Alberto Cereda

Erschienen in: Current Cardiology Reports | Ausgabe 3/2024

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Abstract

Purpose of Review

Coronavirus disease-2019 (COVID-19) vaccines have been related to rare cases of acute myocarditis, occurring between 1 in 10,000 and 1 in 100,000 individuals, approximately. Incidence of COVID-19 vaccine-associated myocarditis varies with age, sex, and type of vaccine. Although most patients with acute myocarditis temporally associated with COVID-19 vaccines have an uneventful course, a small subpopulation presents with cardiogenic shock (termed fulminant myocarditis [FM]). This review explored the prevalence, clinical presentation, management, and prognosis of COVID-19 vaccine-associated acute myocarditis, specifically focusing on FM and comparing patients with fulminant versus non-fulminant myocarditis.

Recent Findings

Cases of FM represent about 2–4% (0 to 7.5%) of COVID-19 vaccine-associated acute myocarditis cases, and mortality is around 1%, ranging between 0 and 4.4%. First, we identified 40 cases of FM up to February 2023 with sufficient granular data from case reports and case series of COVID-19 vaccine-associated acute myocarditis that occurred within 30 days from the last vaccine injection. This population was compared with 294 cases of non-fulminant acute myocarditis identified in the literature during a similar time. Patients with FM were older (48 vs. 27 years), had a larger proportion of women (58% vs. 9%), and mainly occurred after the first shot compared with non-fulminant cases (58% vs. 16%). The reported mortality was 27% (11 out of 40), in line with non-vaccine-associated fulminant myocarditis. These data were in agreement with 36 cases of FM from a large Korean registry. Herein, we reviewed the clinical features, imaging results, and histological findings of COVID-19 vaccine-associated fulminant myocarditis.

Summary

In conclusion, COVID-19 vaccine-associated FM differs from non-fulminant forms, suggesting potential specific mechanisms in these rare and severe forms. Mortality in vaccine-associated FM remains high, in line with other forms of FM.

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Amemiya K, Kobayashi T, Kataoka Y, Iwai T, Nakagawa S, Morita Y, Ohta-Ogo K, Matsumoto M, Ikeda Y, Katano H, et al. Myocarditis after COVID-19 mRNA vaccination in three young adult males: significance of biopsy in vaccine-associated myocarditis. Pathol Int. 2022;72:385–7. https://doi.org/10.1111/pin.13234.CrossRefPubMedPubMedCentral

Titel: Fulminant Myocarditis Temporally Associated with COVID-19 Vaccination
verfasst von: Enrico Ammirati
Nicolina Conti
Matteo Palazzini
Matteo Rocchetti
Andrea Spangaro
Andrea Garascia
Laura Lupi
Alberto Cereda
Publikationsdatum: 07.02.2024
Verlag: Springer US
Erschienen in: Current Cardiology Reports / Ausgabe 3/2024
Print ISSN: 1523-3782
Elektronische ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-024-02021-w

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Fulminant Myocarditis Temporally Associated with COVID-19 Vaccination

Abstract

Purpose of Review

Recent Findings

Summary

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Abstract

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