Erschienen in:
29.11.2023 | Review
Liquid biopsy in the setting of leptomeningeal metastases: a systematic review and meta-analysis
verfasst von:
Jeremiah H. Wijaya, Utsav D. Patel, Miguel D. Quintero-Consuegra, Maria P. Aguilera-Peña, Humberto J. Madriñán-Navia, Aulia W. Putra, Julius July, Saurabh Kataria
Erschienen in:
Journal of Neuro-Oncology
|
Ausgabe 3/2023
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Abstract
Purpose
The blood-brain barrier can prevent circulating tumor DNA (ctDNA) derived from the central nervous system from entering the blood making it challenging to evaluate molecular features of leptomeningeal metastasis (LM). Accordingly, we sought to systematically compare the diagnostic power or significance of ctDNA derived from cerebrospinal fluid (CSF) compared to plasma ctDNA in patients with LM.
Methods
A systematic review and meta-analysis was performed under the PRISMA guideline. We used PubMed, EMBASE, and the EuroPMC to search the literature using combinations of the following terms: circulating tumor DNA, ctDNA, circulating tumor cell, brain metastasis, leptomeningeal metastasis, outcome(s), and prognosis. We included all available English language studies that compared the diagnostic significance of CSF derived and serum ctDNA. All eligible studies level of bias was assessed using the New Castle Ottawa Scale (NOS).
Results
Our meta-analysis from 6 included studies (n = 226) that confirmed the diagnostic power of liquid biopsies in detecting genomic alteration is better when taking a CSF-derived samples than from the plasma (RR 1.46 [0.93; 2.29]; I2 = 92%; p-value < 0.01).
Conclusion
CSF ctDNA is better at describing molecular landscape for LM; such an understanding may ultimately help inform patient treatment and responses to therapy.