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Sleep and Breathing

Erschienen in:

07.10.2022 | Neurology • Original Article

NREM sleep loss increases neurofilament light chain levels in APP/PS1 and C57BL/6 J mice

verfasst von: Shunjie Liu, Zhiying Zhang, Shuangming Shi, Yangyang Meng, Xiaofeng Zhang, Qingfeng Lei, Zhong Li

Erschienen in: Sleep and Breathing | Ausgabe 4/2023

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Abstract

Purpose

Sleep disturbances exacerbate the progression of Alzheimer’s disease (AD), but disturbances of non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep may have different effects. Neurofilament light chain (NfL), an axon-specific protein, is an indicator of the severity of neuronal apoptosis. To investigate whether or not NREM or REM sleep is crucial to neuronal survival, we examined the effects of induced NREM or REM sleep loss on NfL levels in APP/PS1 mice, a model of AD, and their wild-type (WT) C57BL/6 J littermates.

Methods

At 6 months of age, WT mice and AD mice were equally divided into six groups, namely, the WT-normal sleep (S), WT-total sleep deprivation (TSD), WT-REM deprivation (RD), AD-S, AD-TSD and AD-RD groups, according to the type of sleep intervention applied. All mice underwent 6 days of sleep intervention. Cerebrospinal fluid (CSF) and plasma NfL levels were measured at baseline and on days 2, 4 and 6, and spatial memory was assessed in the Morris water maze (MWM) test.

Results

Among the 18 WT and 18 AD mice, CSF and plasma NfL levels were higher in AD-TSD mice than in AD-S or AD-RD mice, while no significant difference was observed between the latter two groups. In AD-TSD mice, CSF and plasma NfL levels increased with the duration of sleep deprivation. A similar pattern of results was observed for the WT groups.

Conclusions

NREM sleep loss may increase CSF and plasma NfL levels in both WT and AD mice.

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Titel: NREM sleep loss increases neurofilament light chain levels in APP/PS1 and C57BL/6 J mice
verfasst von: Shunjie Liu
Zhiying Zhang
Shuangming Shi
Yangyang Meng
Xiaofeng Zhang
Qingfeng Lei
Zhong Li
Publikationsdatum: 07.10.2022
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 4/2023
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-022-02719-7

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NREM sleep loss increases neurofilament light chain levels in APP/PS1 and C57BL/6 J mice