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Erschienen in:

18.03.2023 | Short Communication

Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV

verfasst von: Carrie D. Johnston, Erika G. Marques de Menezes, Scott Bowler, Eugenia L. Siegler, Courtney Friday, Philip J. Norris, Michelle C. Rice, Mary E. Choi, Marshall J. Glesby, Lishomwa C. Ndhlovu

Erschienen in: Journal of NeuroVirology | Ausgabe 2/2023

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Abstract

Extracellular vesicles (EVs) are nanoparticles with a role in intercellular communication. Cell-free mitochondrial DNA (cf-mtDNA) has been associated with cognitive dysfunction in people with HIV (PWH). We conducted a nested case–control study to test the hypothesis that plasma EVs are associated with cf-mtDNA and cognitive dysfunction in older PWH. A machine learning-based model identified total EVs, including select EV subpopulations, as well as urine cf-mtDNA and 4-meter walk time carry power to predict the neurocognitive impairment. These features resulted in an AUC-ROC of 0.845 + / − 0.109 (0.615, 1.00).

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Titel: Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV
verfasst von: Carrie D. Johnston
Erika G. Marques de Menezes
Scott Bowler
Eugenia L. Siegler
Courtney Friday
Philip J. Norris
Michelle C. Rice
Mary E. Choi
Marshall J. Glesby
Lishomwa C. Ndhlovu
Publikationsdatum: 18.03.2023
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 2/2023
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-023-01122-6

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