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Herzschrittmachertherapie + Elektrophysiologie

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14.10.2020 | Original Contributions

Retrospective analysis of FIRM-guided ablation in patients with recurrent atrial fibrillation: a single-center study

verfasst von: Stefan Georg Spitzer, MD, FESC, FHRS, László Károlyi, MD, Carola Rämmler, Dipl.-Ing., Mirko Zieschank, Dipl.-Ing. (BA), Anke Langbein, MD

Erschienen in: Herzschrittmachertherapie + Elektrophysiologie | Ausgabe 4/2020

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Abstract

Background

Ablation of recurrent atrial fibrillation (AF) is common. Studies indicate that AF recurrence is primarily due to pulmonary vein (PV) re-conduction. This retrospective analysis characterized and evaluated recurrent AF patients using focal impulse and rotor mapping (FIRM) plus PV re-isolation, with follow up at 3, 6, 12, and 24 months after the repeat ablation.

Methods and results

Patients (consecutive, n = 100) underwent FIRM-guided ablation followed by conventional PV re-isolation for recurrent AF treatment. All FIRM patients had failed one or more conventional ablation procedures (1.4 ± 0.08) for paroxysmal (14%), persistent (15%), and long-standing persistent (71%) AF. Stable rotors were identified in 97/100 patients: 60% in the right atrium (RA) and 82% in left atrium (LA) (mean 1.5 ± 0.8 and 2.1 ± 1.2 per patient, respectively). No correlation was noted between the previous number of ablations, AF duration, or LA diameter to the number of rotors (R² = 0.0039, R² = 0.0017, and R² = 0.006, respectively). In this limited observation, only 22% of identified rotors were associated with proximity to low voltage areas. The 12- and 24-month arrhythmia free rate was 93% (13/14) and 92% (12/13) for paroxysmal AF, 60% (9/15) and 47% (7/15) for persistent AF, and 70% (48/69) and 64% (43/67) for long-standing persistent AF, respectively, after a single FIRM procedure and re-isolation of the veins.

Conclusions

The data show a benefit for FIRM-guided ablation in recurrent AF at 12 months. No correlation was found between rotors and tissue characterization, AF duration, or previous number of ablations, suggesting that rotors may play an independent role in maintaining recurrent AF after prior failed ablation.

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Titel: Retrospective analysis of FIRM-guided ablation in patients with recurrent atrial fibrillation: a single-center study
verfasst von: Stefan Georg Spitzer, MD, FESC, FHRS
László Károlyi, MD
Carola Rämmler, Dipl.-Ing.
Mirko Zieschank, Dipl.-Ing. (BA)
Anke Langbein, MD
Publikationsdatum: 14.10.2020
Verlag: Springer Medizin
Erschienen in: Herzschrittmachertherapie + Elektrophysiologie / Ausgabe 4/2020
Print ISSN: 0938-7412
Elektronische ISSN: 1435-1544
DOI: https://doi.org/10.1007/s00399-020-00724-5

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