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Current Treatment Options in Gastroenterology
Erschienen in: Current Treatment Options in Gastroenterology 3/2022

07.07.2022 | Liver (E Tapper, Section Editor)

The Role of Statins in Cirrhosis

verfasst von: Carlos Moctezuma-Velazquez, MD, MSc, Juan Gonzalez Abraldes, MD, PhD

Erschienen in: Current Treatment Options in Gastroenterology | Ausgabe 3/2022

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Abstract

Purpose of review

To critically analyze current evidence regarding the role of statins in cirrhosis with particular emphasis on the source of the evidence.
Recent findings.
Most evidence is from observational studies; the few data of clinical trials does not support using statins to prevent rebleeding, but suggests that properly designed trials should be conducted to assess a potential disease-modifying effect. Current evidence is not enough to support their use in prevention of decompensation, acute-on-chronic liver failure, hepatocellular carcinoma, infection, or mortality. Regarding safety, outside of clinical trials, statins are not contraindicated in patients with compensated cirrhosis. In patients with early decompensated cirrhosis, they should be used with caution or deprescribed. In Child–Pugh C patients, statins are contraindicated.

Summary

Current evidence is not enough to support the use of statins in patients with cirrhosis for any other indication than treatment of dyslipidemia and/or to reduce cardiovascular risk. However, current ongoing trials will answer if their role can be expanded to improve cirrhosis outcomes.
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Metadaten
Titel
The Role of Statins in Cirrhosis
verfasst von
Carlos Moctezuma-Velazquez, MD, MSc
Juan Gonzalez Abraldes, MD, PhD
Publikationsdatum
07.07.2022
Verlag
Springer US
Erschienen in
Current Treatment Options in Gastroenterology / Ausgabe 3/2022
Print ISSN: 1092-8472
Elektronische ISSN: 1534-309X
DOI
https://doi.org/10.1007/s11938-022-00394-x

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„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

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