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Erschienen in: Basic Research in Cardiology 1/2021

01.12.2021 | Review

Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases

verfasst von: Ioanna Andreadou, Panagiotis Efentakis, Katie Frenis, Andreas Daiber, Rainer Schulz

Erschienen in: Basic Research in Cardiology | Ausgabe 1/2021

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Abstract

Thiol-based redox compounds, namely thioredoxins (Trxs), glutaredoxins (Grxs) and peroxiredoxins (Prxs), stand as a pivotal group of proteins involved in antioxidant processes and redox signaling. Glutaredoxins (Grxs) are considered as one of the major families of proteins involved in redox regulation by removal of S-glutathionylation and thereby reactivation of other enzymes with thiol-dependent activity. Grxs are also coupled to Trxs and Prxs recycling and thereby indirectly contribute to reactive oxygen species (ROS) detoxification. Peroxiredoxins (Prxs) are a ubiquitous family of peroxidases, which play an essential role in the detoxification of hydrogen peroxide, aliphatic and aromatic hydroperoxides, and peroxynitrite. The Trxs, Grxs and Prxs systems, which reversibly induce thiol modifications, regulate redox signaling involved in various biological events in the cardiovascular system. This review focuses on the current knowledge of the role of Trxs, Grxs and Prxs on cardiovascular pathologies and especially in cardiac hypertrophy, ischemia/reperfusion (I/R) injury and heart failure as well as in the presence of cardiovascular risk factors, such as hypertension, hyperlipidemia, hyperglycemia and metabolic syndrome. Further studies on the roles of thiol-dependent redox systems in the cardiovascular system will support the development of novel protective and therapeutic strategies against cardiovascular diseases.
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Metadaten
Titel
Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases
verfasst von
Ioanna Andreadou
Panagiotis Efentakis
Katie Frenis
Andreas Daiber
Rainer Schulz
Publikationsdatum
01.12.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Basic Research in Cardiology / Ausgabe 1/2021
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-021-00885-5

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