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Basic Research in Cardiology

Ausgabe 1/2021

Inhalt (66 Artikel)

Open Access Original Contribution

Plasminogen activator inhibitor-1 reduces cardiac fibrosis and promotes M2 macrophage polarization in inflammatory cardiomyopathy

Christian Baumeier, Felicitas Escher, Ganna Aleshcheva, Heiko Pietsch, Heinz-Peter Schultheiss

Open Access Review

DGK and DZHK position paper on genome editing: basic science applications and future perspective

Ralf P. Brandes, Anne Dueck, Stefan Engelhardt, Manuel Kaulich, Christian Kupatt, Maria Teresa De Angelis, Matthias S. Leisegang, Ferdinand le Noble, Alessandra Moretti, Oliver J. Müller, Boris V. Skryabin, Thomas Thum, Wolfgang Wurst

Original Contribution

Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1

Qiong Lai, Guangying Yuan, Le Shen, Lu Zhang, Fei Fu, Zeliang Liu, Yuanyuan Zhang, Junping Kou, Shijia Liu, Boyang Yu, Fang Li

Original Contribution

Effect of COMBinAtion therapy with remote ischemic conditioning and exenatide on the Myocardial Infarct size: a two-by-two factorial randomized trial (COMBAT-MI)

Bruno García del Blanco, Imanol Otaegui, José F. Rodríguez-Palomares, Antoni Bayés-Genis, Eduard Fernández-Nofrerías, Victoria Vilalta del Olmo, Xavier Carrillo, Borja Ibáñez, Fernando Worner, Juan Casanova, Eva Pueo, Jose R. González-Juanatey, Javier López-Pais, Alfredo Bardají, Gil Bonet, Mónica Fuertes, Antonio Rodríguez-Sinovas, Marisol Ruiz-Meana, Javier Inserte, Ignasi Barba, Sandra Gómez-Talavera, Gerard Martí, Bernat Serra, Neus Bellera, Manuel Ojeda-Ramos, Hug Cuellar, Filipa Valente, Maria Ángeles Carmona, Elisabet Miró-Casas, Josep R. Marsal, Antonia Sambola, Rosa M. Lidón, Jordi Bañeras, Jaime Elízaga, Ferran Padilla, José A. Barrabés, Derek J. Hausenloy, Ignacio Ferreira-González, David García-Dorado

Open Access Review

Neuronal guidance proteins in cardiovascular inflammation

Marius Keller, Valbona Mirakaj, Michael Koeppen, Peter Rosenberger

Open Access Original Contribution

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection

Carl Christoph Goetzke, Nadine Althof, Hannah Louise Neumaier, Arndt Heuser, Ziya Kaya, Meike Kespohl, Karin Klingel, Antje Beling

Open Access Original Contribution

4-hydroxytamoxifen does not deteriorate cardiac function in cardiomyocyte-specific MerCreMer transgenic mice

Andre Heinen, Stefanie Gödecke, Ulrich Flögel, Dominika Miklos, Katharina Bottermann, André Spychala, Axel Gödecke

Original Contribution

Vascular conditioning prevents adverse left ventricular remodelling after acute myocardial infarction: a randomised remote conditioning study

Ignatios Ikonomidis, Dimitrios Vlastos, Ioanna Andreadou, Maria Gazouli, Panagiotis Efentakis, Maria Varoudi, George Makavos, Alkistis Kapelouzou, John Lekakis, John Parissis, Spiridon Katsanos, Damianos Tsilivarakis, Derek J. Hausenloy, Dimitrios Alexopoulos, Dennis V. Cokkinos, Hans-Eric Bøtker, Efstathios K. Iliodromitis

Open Access Original Contribution

AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism

Cécile Dufeys, Evangelos-Panagiotis Daskalopoulos, Diego Castanares-Zapatero, Simon J. Conway, Audrey Ginion, Caroline Bouzin, Jérôme Ambroise, Bertrand Bearzatto, Jean-Luc Gala, Stephane Heymans, Anna-Pia Papageorgiou, Stefan Vinckier, Julien Cumps, Jean-Luc Balligand, Maarten Vanhaverbeke, Peter Sinnaeve, Stefan Janssens, Luc Bertrand, Christophe Beauloye, Sandrine Horman

Open Access Original Contribution

CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes

Kathryn G. Helmstadter, Senka Ljubojevic-Holzer, Brent M. Wood, Khanha D. Taheri, Simon Sedej, Jeffrey R. Erickson, Julie Bossuyt, Donald M. Bers

Original Contribution

Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes

Patrick Lugenbiel, Katharina Govorov, Pascal Syren, Ann-Kathrin Rahm, Teresa Wieder, Maximilian Wunsch, Nadine Weiberg, Emili Manolova, Dominik Gramlich, Rasmus Rivinius, Daniel Finke, Lorenz H. Lehmann, Patrick A. Schweizer, Derk Frank, Fadwa A. El Tahry, Claus Bruehl, Tanja Heimberger, Steffi Sandke, Tanja Weis, Patrick Most, Bastian Schmack, Arjang Ruhparwar, Matthias Karck, Norbert Frey, Hugo A. Katus, Dierk Thomas

Open Access Original Contribution

Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant

He Jiang, Charlotte Hooper, Matthew Kelly, Violetta Steeples, Jillian N. Simon, Julia Beglov, Amar J. Azad, Lisa Leinhos, Pauline Bennett, Elisabeth Ehler, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Roman Fischer, Raphael Heilig, Henrik Isackson, Mehroz Ehsan, Giannino Patone, Norbert Huebner, Benjamin Davies, Hugh Watkins, Katja Gehmlich

Original Contribution

SAIL: a new conserved anti-fibrotic lncRNA in the heart

Shenjian Luo, Mingyu Zhang, Hao Wu, Xin Ding, Danyang Li, Xue Dong, Xiaoxi Hu, Shuang Su, Wendi Shang, Jiaxu Wu, Hongwen Xiao, Wanqi Yang, Qi Zhang, Jifan Zhang, Yanjie Lu, Zhenwei Pan

Original Contribution

Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles

Thomas Ravn Lassen, Jesper Just, Marie Vognstoft Hjortbak, Nichlas Riise Jespersen, Katrine Tang Stenz, Tingting Gu, Yan Yan, Junyi Su, Jakob Hansen, Rikke Bæk, Malene Møller Jørgensen, Jens Randel Nyengaard, Steen Buus Kristiansen, Kim Ryun Drasbek, Jørgen Kjems, Hans Erik Bøtker

Open Access Original Contribution

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Patrick M. Siegel, István Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto-Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, Maximilian Mauler, Laura Hollederer, Martin Moser, Christoph Bode, Michael W. Parker, Karlheinz Peter, Philipp Diehl

Open Access Original Contribution

Cardiomyocyte depolarization triggers NOS-dependent NO transient after calcium release, reducing the subsequent calcium transient

Matias Mosqueira, Roland Konietzny, Carolin Andresen, Chao Wang, Rainer H.A. Fink

Original Contribution

miR-106a–363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury

Ji-Hye Jung, Gentaro Ikeda, Yuko Tada, Daniel von Bornstädt, Michelle R. Santoso, Christine Wahlquist, Siyeon Rhee, Young-Jun Jeon, Anthony C. Yu, Connor G. O’brien, Kristy Red-Horse, Eric A. Appel, Mark Mercola, Joseph Woo, Phillip C. Yang

Open Access Original Contribution

Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning

Christine Hirschhäuser, Alessio Lissoni, Philipp Maximilian Görge, Paul D. Lampe, Jacqueline Heger, Klaus-Dieter Schlüter, Luc Leybaert, Rainer Schulz, Kerstin Boengler

Open Access Review

Adenosine and adenosine receptor-mediated action in coronary microcirculation

Ying Zhang, Bernhard Wernly, Xin Cao, S. Jamal Mustafa, Yong Tang, Zhichao Zhou

Open Access Review

Cytokines as therapeutic targets for cardio- and cerebrovascular diseases

Luca Liberale, Stefano Ministrini, Federico Carbone, Giovanni G. Camici, Fabrizio Montecucco

Open Access Original Contribution

Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans

Gábor Á. Fülöp, Attila Oláh, Tamas Csipo, Árpád Kovács, Róbert Pórszász, Roland Veress, Balázs Horváth, László Nagy, Beáta Bódi, Miklós Fagyas, Solveig Lind Helgadottir, Viktor Bánhegyi, Béla Juhász, Mariann Bombicz, Daniel Priksz, Peter Nanasi Jr, Béla Merkely, István Édes, Zoltán Csanádi, Zoltán Papp, Tamás Radovits, Attila Tóth

Open Access Original Contribution

SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

Natalie M. Landry, Sunil G. Rattan, Krista L. Filomeno, Thomas W. Meier, Simon C. Meier, Sarah J. Foran, Claire F. Meier, Navid Koleini, Robert R. Fandrich, Elissavet Kardami, Todd A. Duhamel, Ian M. C. Dixon

Open Access Original Contribution

Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis

Gesine M. Dittrich, Natali Froese, Xue Wang, Hannah Kroeger, Honghui Wang, Malgorzata Szaroszyk, Mona Malek-Mohammadi, Julio Cordero, Merve Keles, Mortimer Korf-Klingebiel, Kai C. Wollert, Robert Geffers, Manuel Mayr, Simon J. Conway, Gergana Dobreva, Johann Bauersachs, Joerg Heineke

Open Access Original Contribution

Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes

Helmut Raphael Lieder, Felix Braczko, Nilgün Gedik, Merlin Stroetges, Gerd Heusch, Petra Kleinbongard

Open Access Original Contribution

Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure

Dongze Zhang, Wenfeng Hu, Huiyin Tu, Bryan T. Hackfort, Bin Duan, Wanfen Xiong, Michael C. Wadman, Yu-Long Li

Open Access Original Contribution

Deoxyribonuclease 1 Q222R single nucleotide polymorphism and long-term mortality after acute myocardial infarction

Thomas M. Hofbauer, Andreas Mangold, Anna S. Ondracek, Adelheid Panzenböck, Thomas Scherz, Julian Müller, Klaus Distelmaier, Veronika Seidl, Stefan Kastl, Martina Müller-Nurasyid, Annette Peters, Konstantin Strauch, Robert Winker, Evelyne Wohlschläger-Krenn, Sonja Nistler, Irene M. Lang

Open Access Original Contribution

HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype

Yanjiao Li, Min Dong, Qing Wang, Santosh Kumar, Rui Zhang, Wanwen Cheng, Jiaqing Xiang, Gang Wang, Kunfu Ouyang, Ruxing Zhou, Yaohong Xie, Yishen Lu, Jing Yi, Haixia Duan, Jie Liu

Open Access Original Contribution

Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects

Katie Frenis, Johanna Helmstädter, Yue Ruan, Eva Schramm, Sanela Kalinovic, Swenja Kröller-Schön, Maria Teresa Bayo Jimenez, Omar Hahad, Matthias Oelze, Subao Jiang, Philip Wenzel, Clemens J. Sommer, Katrin B. M. Frauenknecht, Ari Waisman, Adrian Gericke, Andreas Daiber, Thomas Münzel, Sebastian Steven

Open Access Original Contribution

Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke

Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N. Christie, Shefeeq M. Theparambil, Sean M. Davidson, Frank Reimann, Stefan Trapp, Derek M. Yellon, Alexander V. Gourine

Open Access Original Contribution

Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?

Maaike te Lintel Hekkert , Gary Newton, Kathryn Chapman, Rehan Aqil, Robert Downham, Robert Yan, Daphne Merkus, Gavin Whitlock, Charlotte A. L. Lane, Darren Cawkill, Trevor Perrior, Dirk J. Duncker, Michael D. Schneider

Original Contribution

Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in Kv channels

Adam G. Goodwill, Hana E. Baker, Gregory M. Dick, Patricia E. McCallinhart, Chastidy A. Bailey, Scott M. Brown, Joshua J. Man, Darla L. Tharp, Hannah E. Clark, Bianca S. Blaettner, Iris Z. Jaffe, Douglas K. Bowles, Aaron J. Trask, Johnathan D. Tune, Shawn B. Bender

Original Contribution

Translation of experimental cardioprotective capability of P2Y12 inhibitors into clinical outcome in patients with ST-elevation myocardial infarction

Marie V. Hjortbak, Kevin K. W. Olesen, Jacob M. Seefeldt, Thomas R. Lassen, Rebekka V. Jensen, Alexander Perkins, Matthew Dodd, Tim Clayton, Derek Yellon, Derek J. Hausenloy, Hans Erik Bøtker

Open Access Editorial

The platelet paradox of injury versus protection in myocardial infarction—has it been overlooked?

Petra Kleinbongard, Ioanna Andreadou, Gemma Vilahur

Open Access Original Contribution

AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure

Anca Remes, Andreas H. Wagner, Nesrin Schmiedel, Markus Heckmann, Theresa Ruf, Lin Ding, Andreas Jungmann, Frauke Senger, Hugo A. Katus, Nina D. Ullrich, Norbert Frey, Markus Hecker, Oliver J. Müller

Review

Pathogenesis of arrhythmogenic cardiomyopathy: role of inflammation

Yen-Nien Lin, Ahmed Ibrahim, Eduardo Marbán, Eugenio Cingolani

Open Access Original Contribution

Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice

Jonas Gregorius, Chen Wang, Oumaima Stambouli, Tanja Hussner, Yachao Qi, Tobias Tertel, Verena Börger, Ayan Mohamud Yusuf, Nina Hagemann, Dongpei Yin, Robin Dittrich, Yanis Mouloud, Fabian D. Mairinger, Fouzi El Magraoui, Aurel Popa-Wagner, Christoph Kleinschnitz, Thorsten R. Doeppner, Matthias Gunzer, Helmut E. Meyer, Bernd Giebel, Dirk M. Hermann

Open Access Original Contribution

Exercise-induced peptide TAG-23 protects cardiomyocytes from reperfusion injury through regulating PKG–cCbl interaction

Zijie Cheng, Hao Zhang, Li Zhang, Xuejun Wang, Qijun Zhang, Mengwen Feng, Deliang Hu, Hua Li, Lingmei Qian

Open Access Original Contribution

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants

Julian U. G. Wagner, Denisa Bojkova, Mariana Shumliakivska, Guillermo Luxán, Luka Nicin, Galip S. Aslan, Hendrik Milting, Joshua D. Kandler, Andreas Dendorfer, Andreas W. Heumueller, Ingrid Fleming, Sofia-Iris Bibli, Tobias Jakobi, Christoph Dieterich, Andreas M. Zeiher, Sandra Ciesek, Jindrich Cinatl, Stefanie Dimmeler

Review

Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases

Ioanna Andreadou, Panagiotis Efentakis, Katie Frenis, Andreas Daiber, Rainer Schulz

Original Contribution

Intravenous metoprolol during ongoing STEMI ameliorates markers of ischemic injury: a METOCARD-CNIC trial electrocardiographic study

Raquel Díaz-Munoz, María José Valle-Caballero, Javier Sanchez-Gonzalez, Gonzalo Pizarro, Juan Carlos García-Rubira, Noemi Escalera, Valentin Fuster, Rodrigo Fernández-Jiménez, Borja Ibanez

Open Access Original Contribution

Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration

Jiao Jiao, Shujie He, Yiqiu Wang, Yuzhi Lu, Muyang Gu, Dan Li, Tingting Tang, Shaofang Nie, Min Zhang, Bingjie Lv, Jingyong Li, Ni Xia, Xiang Cheng

Original Contribution

Atg5 knockdown induces age-dependent cardiomyopathy which can be rescued by repeated remote ischemic conditioning

Fangfei Wang, Quan He, Zhiqian Gao, Andrew N. Redington

Open Access Original Contribution

LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway

Ning Liu, Masaharu Kataoka, Yingchao Wang, Linbin Pu, Xiaoxuan Dong, Xuyang Fu, Feng Zhang, Feng Gao, Tian Liang, Jianqiu Pei, Changchen Xiao, Qiongzi Qiu, Tingting Hong, Qiming Chen, Jing Zhao, Lianlian Zhu, Junhua He, Xiaoyun Hu, Yu Nie, Wei Zhu, Hong Yu, Douglas B. Cowan, Xinyang Hu, Jian’an Wang, Da-Zhi Wang, Jinghai Chen

Open Access Review

Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases

Yuliang Feng, Wei Huang, Christian Paul, Xingguo Liu, Sakthivel Sadayappan, Yigang Wang, Siim Pauklin

Open Access Original Contribution

Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors

Jens van de Wouw, Oana Sorop, Ruben W. A. van Drie, Jaap A. Joles, A. H. Jan Danser, Marianne C. Verhaar, Daphne Merkus, Dirk J. Duncker

Open Access Original Contribution

Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities

Jens van de Wouw, Jarno J. Steenhorst, Oana Sorop, Ruben W. A. van Drie, Piotr A. Wielopolski, Alex Kleinjan, Alexander Hirsch, Dirk J. Duncker, Daphne Merkus

Open Access Practical Guideline

IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action

Sandrine Lecour, Ioanna Andreadou, Hans Erik Bøtker, Sean M. Davidson, Gerd Heusch, Marisol Ruiz-Meana, Rainer Schulz, Coert J. Zuurbier, Péter Ferdinandy, Derek J. Hausenloy, Pavle Adamovski, Ioanna Andreadou, Saime Batirel, Monika Barteková, Luc Bertrand, Christophe Beauloye, David Biedermann, Vilmante Borutaite, Hans Erik Bøtker, Stefan Chlopicki, Maija Dambrova, Sean Davidson, Yvan Devaux, Fabio Di Lisa, Dragan Djuric, David Erlinge, Ines Falcao-Pires, Péter Ferdinandy, Eleftheria Galatou, Alfonso Garcia-Sosa, Henrique Girao, Zoltan Giricz, Mariann Gyongyosi, Derek J Hausenloy, Donagh Healy, Gerd Heusch, Vladimir Jakovljevic, Jelena Jovanic, George Kararigas, Risto Kerkal, Frantisek Kolar, Brenda Kwak, Przemysław Leszek, Edgars Liepinsh, Jacob Lonborg, Sarah Longnus, Jasna Marinovic, Danina Mirela Muntean, Lana Nezic, Michel Ovize, Pasquale Pagliaro, Clarissa Pedrosa Da Costa Gomes, John Pernow, Andreas Persidis, Søren Erik Pischke, Bruno Podesser, Ines Potočnjak, Fabrice Prunier, Tanya Ravingerova, Marisol Ruiz-Meana, Alina Serban, Katrine Slagsvold, Rainer Schulz, Niels van Royen, Belma Turan, Marko Vendelin, Stewart Walsh, Nace Zidar, Coert Zuurbier, Derek Yellon

Original Contribution

The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner

Yongyi Bai, Jingrong Wang, Ying Chen, Tingting Lv, Xiaojian Wang, Chunlei Liu, Hao Xue, Kunlun He, Lan Sun

Original Contribution

The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy

Hualu Zhang, Ningzhi Yang, Haiyan He, Junwu Chai, Xinxin Cheng, Huanhuan Zhao, Dongming Zhou, Tianming Teng, Xiangrong Kong, Qing Yang, Zhelong Xu

Original Contribution

Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level

Man Rao, Xiliang Wang, Guangran Guo, Li Wang, Shi Chen, Pengbin Yin, Kai Chen, Liang Chen, Zemin Zhang, Xiao Chen, Xueda Hu, Shengshou Hu, Jiangping Song

Open Access Review

Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function

Stefano Comità, Saveria Femmino, Cecilia Thairi, Giuseppe Alloatti, Kerstin Boengler, Pasquale Pagliaro, Claudia Penna

Open Access Original Contribution

Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation

Setareh Orth-Alampour, Nathalie Gayrard, Silvia Salem, Shruti Bhargava, Vera Jankowski, Bernard Jover, Cécile Notarnicola, Heidi Noels, Emiel P. C. van der Vorst, Christoph Kuppe, Michael Wolf, Claudia Goettsch, Wendy Theelen, Heike Bruck, Danilo Fliser, Joseph Loscalzo, Zhuojun Wu, Nikolaus Marx, Walter Zidek, Àngel Argilés, Joachim Jankowski

Open Access Original Contribution

Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors

Bence Hegyi, Risto-Pekka Pölönen, Kim T. Hellgren, Christopher Y. Ko, Kenneth S. Ginsburg, Julie Bossuyt, Mark Mercola, Donald M. Bers

Open Access Original Contribution

Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy

Rohin Francis, Jun Chong, Manish Ramlall, Chiara Bucciarelli-Ducci, Tim Clayton, Matthew Dodd, Thomas Engstrøm, Richard Evans, Vanessa M. Ferreira, Marianna Fontana, John P. Greenwood, Rajesh K. Kharbanda, Won Yong Kim, Tushar Kotecha, Jacob T. Lønborg, Anthony Mathur, Ulla Kristine Møller, James Moon, Alexander Perkins, Roby D. Rakhit, Derek M. Yellon, Hans Erik Bøtker, Heerajnarain Bulluck, Derek J. Hausenloy

Open Access Original Contribution

Effects of remote ischemic preconditioning (RIPC) and chronic remote ischemic preconditioning (cRIPC) on levels of plasma cytokines, cell surface characteristics of monocytes and in-vitro angiogenesis: a pilot study

Lars Hummitzsch, Karina Zitta, Lena Fritze, Jonas Monnens, Patrick Vollertsen, Matthias Lindner, Rene Rusch, Katharina Hess, Matthias Gruenewald, Markus Steinfath, Fred Fändrich, Rouven Berndt, Martin Albrecht

Open Access Original Contribution

Anthracycline-free tumor elimination in mice leads to functional and molecular cardiac recovery from cancer-induced alterations in contrast to long-lasting doxorubicin treatment effects

Stefan Pietzsch, Katharina Wohlan, James T. Thackeray, Maren Heimerl, Sven Schuchardt, Michaela Scherr, Melanie Ricke-Hoch, Denise Hilfiker-Kleiner

Open Access Original Contribution

Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes

Vladimir Bogdanov, Andrew M. Soltisz, Nicolae Moise, Galina Sakuta, Benjamin Hernandez Orengo, Paul M. L. Janssen, Seth H. Weinberg, Jonathan P. Davis, Rengasayee Veeraraghavan, Sandor Györke

Original Contribution

Single-cell transcriptomic identified HIF1A as a target for attenuating acute rejection after heart transplantation

Yuan Chang, Xiangjie Li, Qi Cheng, Yiqing Hu, Xiao Chen, Xiumeng Hua, Xuexin Fan, Menghao Tao, Jiangping Song, Shengshou Hu

Open Access Original Contribution

Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia–reperfusion injury

Su Li, Jinxiang Chen, Muyin Liu, Yuqiong Chen, Yuan Wu, Qiyu Li, Teng Ma, Jinfeng Gao, Yan Xia, Mengkang Fan, Ao Chen, Danbo Lu, Enyong Su, Fei Xu, Zhangwei Chen, Juying Qian, Junbo Ge

Original Contribution

Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection

Doria Boulghobra, Mathilde Dubois, Béatrice Alpha-Bazin, Florence Coste, Maxime Olmos, Sandrine Gayrard, Isabelle Bornard, Gregory Meyer, Jean-Charles Gaillard, Jean Armengaud, Cyril Reboul

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