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Head and Neck Pathology

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16.03.2023 | SPECIAL ISSUE: TOP TEN HEAD AND NECK DIFFERENTIALS

Top Ten Oncocytic Head and Neck Lesions to Contemplate

verfasst von: Martin J. Bullock, Xiaoyin S. Jiang

Erschienen in: Head and Neck Pathology | Ausgabe 1/2023

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Abstract

Background

Oncocytes are a component of many metaplastic and neoplastic lesions throughout the head and neck area, primarily originating in salivary/seromucinous glands and the thyroid gland. In addition, other lesions can contain cells that mimic oncocytes (pseudo-oncocytes); these can be of epithelial or non-epithelial origin.

Methods

Review article.

Results

Oncocytic metaplasia is common in seromucinous glands throughout the upper aerodigestive tract, most notable in the oral cavity, nasopharynx and larynx. The main oncocytic salivary gland neoplasms are Warthin tumor and oncocytoma. Infarction of Warthin tumor may lead to recognition difficulties. Oncocytic subtypes of mucoepidermoid carcinoma and intraductal carcinoma have morphologic and immunohistochemical features that allow distinction from major oncocytic entities. Oncocytic thyroid tumors include adenoma, carcinoma (follicular, papillary and medullary), along with poorly differentiated tumors. Oncocytic papillary sinonasal and middle ear tumors must be distinguished from low grade adenocarcinomas. Pseudo-oncocytic entities include paraganglioma, Langerhans cell histiocytosis, giant cell tumor, rhabdomyoma, and metastatic tumors.

Conclusions

Correct diagnosis of oncocytic head and neck lesions requires a knowledge of the spectrum of possible entities, their characteristic sites of occurrence, architecture, histomorphology, and immunohistochemistry. Oncocytic subtypes of several newly described entities are now recognized. Both epithelial and non-epithelial mimics of oncocytes exist. The molecular features of oncocytic tumors can be helpful in their diagnosis and understanding their pathogenesis.

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Titel: Top Ten Oncocytic Head and Neck Lesions to Contemplate
verfasst von: Martin J. Bullock
Xiaoyin S. Jiang
Publikationsdatum: 16.03.2023
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 1/2023
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-022-01520-y

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Top Ten Oncocytic Head and Neck Lesions to Contemplate

Abstract

Background

Methods

Results

Conclusions

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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