Ausgabe 1/2024
Inhalt (46 Artikel)
Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice
Xiao J. Tong, Gokhan Akdemir, Meetu Wadhwa, Alan S. Verkman, Alex J. Smith
Sex, hormones and cerebrovascular function: from development to disorder
Adeline Collignon, Laurence Dion-Albert, Caroline Ménard, Vanessa Coelho-Santos
Blood–brain borders: a proposal to address limitations of historical blood–brain barrier terminology
Jerome Badaut, Jean-François Ghersi-Egea, Robert G. Thorne, Jan Pieter Konsman
Postnatal meningeal CSF transport is primarily mediated by the arachnoid and pia maters and is not altered after intraventricular hemorrhage-posthemorrhagic hydrocephalus
Shelei Pan, Joshua P. Koleske, Gretchen M. Koller, Grace L. Halupnik, Abdul-Haq O. Alli, Shriya Koneru, Dakota DeFreitas, Sruthi Ramagiri, Jennifer M. Strahle
Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier
Rodnie Colón Ortiz, Stephen Knerler, Lisa B. Fridman, Alicia Mercado, Amira-Storm Price, Jose J. Rosado-Franco, Hannah Wilkins, Bianca R. Flores, Benjamin C. Orsburn, Dionna W. Williams
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats
Vanda Tukacs, Dániel Mittli, Éva Hunyadi-Gulyás, Zsuzsanna Darula, Gábor Juhász, József Kardos, Katalin Adrienna Kékesi
Hydraulic resistance of three-dimensional pial perivascular spaces in the brain
Kimberly A. S. Boster, Jiatong Sun, Jessica K. Shang, Douglas H. Kelley, John H. Thomas
Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/β-catenin axis
Ying Hou, Ye Xie, Xiaoxuan Liu, Yushan Chen, Fangfang Zhou, Binbin Yang
ChOP-CT: quantitative morphometrical analysis of the Hindbrain Choroid Plexus by X-ray micro-computed tomography
Viktória Parobková, Petra Kompaníková, Jakub Lázňovský, Michaela Kavková, Marek Hampl, Marcela Buchtová, Tomáš Zikmund, Jozef Kaiser, Vítězslav Bryja
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension
Jonathan H. Wardman, Søren Norge Andreassen, Trine L. Toft-Bertelsen, Mette Nyholm Jensen, Jens E. Wilhjelm, Bjarne Styrishave, Steffen Hamann, Steffen Heegaard, Alexandra J. Sinclair, Nanna MacAulay
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
Kristine Langthaler, Christopher R. Jones, Lasse Saaby, Christoffer Bundgaard, Birger Brodin
Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature
Jari Jukkola, Mika Kaakinen, Abhishek Singh, Sadegh Moradi, Hany Ferdinando, Teemu Myllylä, Vesa Kiviniemi, Lauri Eklund
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
Yang Hu, Milda Girdenyté, Lieke Roest, Iida Liukkonen, Maria Siskou, Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan
Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data
Christian Mirian, Maria Thastrup, René Mathiasen, Kjeld Schmiegelow, Jesper Velgaard Olsen, Ole Østergaard
Deep learning segmentation of peri-sinus structures from structural magnetic resonance imaging: validation and normative ranges across the adult lifespan
Kilian Hett, Colin D. McKnight, Melanie Leguizamon, Jennifer S. Lindsey, Jarrod J. Eisma, Jason Elenberger, Adam J. Stark, Alexander K. Song, Megan Aumann, Ciaran M. Considine, Daniel O. Claassen, Manus J. Donahue
Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-weighted cohort study
Pao-Hui Tseng, Wan-Ting Huang, Jen-Hung Wang, Bor-Ren Huang, Hsin-Yi Huang, Sheng-Tzung Tsai
Pro-inflammatory cerebrospinal fluid profile of neonates with intraventricular hemorrhage: clinical relevance and contrast with CNS infection
Maria Garcia-Bonilla, Alexander T. Yahanda, Albert M. Isaacs, Brandon Baksh, S. Hassan A. Akbari, Haley Botteron, Diego M. Morales, Rowland H. Han, James P. McAllister II, Amit M. Mathur, Jennifer M. Strahle, Christopher D. Smyser, David D. Limbrick Jr
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance
Abhijit Nirwane, Minkyung Kang, Aravinthan Adithan, Vrishni Maharaj, Felicia Nguyen, Elliot Santaella Aguilar, Ava Nasrollahi, Yao Yao
Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model
Dipak D. Pukale, Kayla Adkins-Travis, Siddhartha R. Aryal, Leah P. Shriver, Gary J. Patti, Nic D. Leipzig
Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve
Diego Rossinelli, Gilles Fourestey, Hanspeter Esriel Killer, Albert Neutzner, Gianluca Iaccarino, Luca Remonda, Jatta Berberat
Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan
Jarrod J. Eisma, Colin D. McKnight, Kilian Hett, Jason Elenberger, Caleb J. Han, Alexander K. Song, Ciaran Considine, Daniel O. Claassen, Manus J. Donahue
Freezing of gait in idiopathic normal pressure hydrocephalus
Carl-Johan Kihlstedt, Jan Malm, Alfonso Fasano, David Bäckström
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture
Tammy-Lynn Tremblay, Wael Alata, Jacqueline Slinn, Ewa Baumann, Christie E. Delaney, Maria Moreno, Arsalan S. Haqqani, Danica B. Stanimirovic, Jennifer J. Hill
The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
Andrew T. Hale, Hunter Boudreau, Rishi Devulapalli, Phan Q. Duy, Travis J. Atchley, Michael C. Dewan, Mubeen Goolam, Graham Fieggen, Heather L. Spader, Anastasia A. Smith, Jeffrey P. Blount, James M. Johnston, Brandon G. Rocque, Curtis J. Rozzelle, Zechen Chong, Jennifer M. Strahle, Steven J. Schiff, Kristopher T. Kahle
Validating the accuracy of real-time phase-contrast MRI and quantifying the effects of free breathing on cerebrospinal fluid dynamics
Pan Liu, Kimi Owashi, Heimiri Monnier, Serge Metanbou, Cyrille Capel, Olivier Balédent
Transient but not chronic hyperglycemia accelerates ocular glymphatic transport
Christine Delle, Xiaowei Wang, Michael Giannetto, Evan Newbold, Weiguo Peng, Ryszard Stefan Gomolka, Antonio Ladrón-de-Guevara, Neža Cankar, Elise Schiøler Nielsen, Celia Kjaerby, Pia Weikop, Yuki Mori, Maiken Nedergaard
Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar, Michael M. Gottesman
Role of aquaporin-4 polarization in extracellular solute clearance
Laura Bojarskaite, Sahar Nafari, Anne Katrine Ravnanger, Mina Martine Frey, Nadia Skauli, Knut Sindre Åbjørsbråten, Lena Catherine Roth, Mahmood Amiry-Moghaddam, Erlend A. Nagelhus, Ole Petter Ottersen, Inger Lise Bogen, Anna E. Thoren, Rune Enger
Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice
Geetika Nehra, Sasivimon Promsan, Ruedeemars Yubolphan, Wijitra Chumboatong, Pornpun Vivithanaporn, Bryan J. Maloney, Anusorn Lungkaphin, Bjoern Bauer, Anika M. S. Hartz
[1-11C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects
Neel H. Mehta, Xiuyuan Wang, Samantha A. Keil, Ke Xi, Liangdong Zhou, Kevin Lee, Wanbin Tan, Edward Spector, Amirhossein Goldan, James Kelly, Nicolas A. Karakatsanis, P. David Mozley, Sadek Nehmeh, J. Levi Chazen, Simon Morin, John Babich, Jana Ivanidze, Silky Pahlajani, Emily B. Tanzi, Leslie Saint-Louis, Tracy Butler, Kewei Chen, Henry Rusinek, Roxana O. Carare, Yi Li, Gloria C. Chiang, Mony J. de Leon
Single-cell analysis of mesenchymal cells in permeable neural vasculature reveals novel diverse subpopulations of fibroblasts
William E. Bastedo, R. Wilder Scott, Martin Arostegui, T. Michael Underhill
SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway
Shigeru Yamada, Tadahiro Hashita, Shota Yanagida, Hiroyuki Sato, Yukuto Yasuhiko, Kaori Okabe, Takamasa Noda, Motohiro Nishida, Tamihide Matsunaga, Yasunari Kanda
Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation
Stéphanie Chasseigneaux, Véronique Cochois-Guégan, Lucas Lecorgne, Murielle Lochus, Sophie Nicolic, Corinne Blugeon, Laurent Jourdren, David Gomez-Zepeda, Stefan Tenzer, Sylvia Sanquer, Valérie Nivet-Antoine, Marie-Claude Menet, Jean-Louis Laplanche, Xavier Declèves, Salvatore Cisternino, Bruno Saubaméa
C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity
Ana Aragón-González, Allan C Shaw, Jannigje R Kok, Florence S Roussel, Cleide dos Santos Souza, Sarah M Granger, Tatyana Vetter, Yolanda de Diego, Kathrin C Meyer, Selina N Beal, Pamela J Shaw, Laura Ferraiuolo
Analysis of ischemic stroke-mediated effects on blood–brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging
Jil Protzmann, Felix Jung, Lars Jakobsson, Linda Fredriksson
Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability
Tingjun Dai, Jianwei Lou, Deyuan Kong, Jinyu Li, Qingguo Ren, Yujing Chen, Sujuan Sun, Yan Yun, Xiaohan Sun, Yiru Yang, Kai Shao, Wei Li, Yuying Zhao, Xiangshui Meng, Chuanzhu Yan, Pengfei Lin, Shuangwu Liu
Choroid plexus immune cell response in murine hydrocephalus induced by intraventricular hemorrhage
Yingfeng Wan, Xiongjie Fu, Tianjie Zhang, Ya Hua, Richard F. Keep, Guohua Xi
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria
Adnan Gopinadhan, Jason M. Hughes, Andrea L. Conroy, Chandy C. John, Scott G. Canfield, Dibyadyuti Datta
The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells
Nana Svane, Alberte Bay Villekjær Pedersen, Anne Rodenberg, Burak Ozgür, Lasse Saaby, Christoffer Bundgaard, Mie Kristensen, Peer Tfelt-Hansen, Birger Brodin
Reduced cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with low b-value diffusion weighted imaging
Gabriela Pierobon Mays, Kilian Hett, Jarrod Eisma, Colin D. McKnight, Jason Elenberger, Alexander K. Song, Ciaran Considine, Wesley T. Richerson, Caleb Han, Adam Stark, Daniel O. Claassen, Manus J. Donahue
Exposure to hyperbaric O2 levels leads to blood-brain barrier breakdown in rodents
Yehuda M. Danino, Ricarina Rabinovitz, Inbar Kirshenboim, Eilam Palzur, Chaim G. Pick, Itamar Ish-Shalom, Yana Golovkin, Yehuda Arieli
Endothelial EGLN3-PKM2 signaling induces the formation of acute astrocytic barrier to alleviate immune cell infiltration after subarachnoid hemorrhage
Mingxu Duan, Xufang Ru, Jiru Zhou, Yuanshu Li, Peiwen Guo, Wenbo Kang, Wenyan Li, Zhi Chen, Hua Feng, Yujie Chen
Breakthroughs in choroid plexus and CSF biology from the first European Choroid plexus Scientific Forum (ECSF)
Laura Pellegrini, Violeta Silva-Vargas, Annarita Patrizi
Intracranial pressure following surgery of an unruptured intracranial aneurysm—a model for normal intracranial pressure in humans
Nicolas Hernandez Norager, Alexander Lilja-Cyron, Casper Schwartz Riedel, Anders Vedel Holst, Sarah Hornshoej Pedersen, Marianne Juhler
Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation
Marco Cavaco, Patrícia Fraga, Javier Valle, Ruben D. M. Silva, Lurdes Gano, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
The circadian clock in the choroid plexus drives rhythms in multiple cellular processes under the control of the suprachiasmatic nucleus
Martin Sládek, Pavel Houdek, Jihwan Myung, Kateryna Semenovykh, Tereza Dočkal, Alena Sumová