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Head and Neck Pathology
Erschienen in: Head and Neck Pathology 1/2023

16.03.2023 | Special Issue: Top Ten Head and Neck Differentials

Top 10 Basaloid Neoplasms of the Sinonasal Tract

verfasst von: Martina Baněčková, Darren Cox

Erschienen in: Head and Neck Pathology | Ausgabe 1/2023

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Abstract

Background

Basaloid neoplasms of the sinonasal tract represent a significant group of tumors with histological overlap but often with different etiologies (i.e., viral, genetics), clinical management, and prognostic significance.

Methods

Review.

Results

“Basaloid” generally refers to cells with coarse chromatin in round nuclei and sparse cytoplasm, resembling cells of epithelial basal layers or imparting an “immature” appearance. Tumors with this characteristic in the sinonasal tract are represented by a spectrum of benign to high-grade malignant neoplasms, such as adenoid cystic carcinoma, NUT carcinoma, sinonasal undifferentiated carcinoma, SWI/SNF complex-deficient carcinomas, and adamantinoma-like Ewing sarcoma.

Conclusion

In some instances, histology alone may be sufficient for diagnosis. However, limited biopsy material or fine-needle aspiration specimens may be particularly challenging. Therefore, often other diagnostic procedures, including a combination of histology, immunohistochemistry (IHC), DNA and RNA testing, and molecular genetics are necessary to establish an accurate diagnosis.
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Metadaten
Titel
Top 10 Basaloid Neoplasms of the Sinonasal Tract
verfasst von
Martina Baněčková
Darren Cox
Publikationsdatum
16.03.2023
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2023
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-022-01508-8

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