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Head and Neck Pathology
Erschienen in: Head and Neck Pathology 1/2023

16.03.2023 | Special Issue: Top Ten Head and Neck Differentials

Top Ten Differentials to Mull Over for Head and Neck Myoepithelial Neoplasms

verfasst von: Lester D. R. Thompson, Bin Xu

Erschienen in: Head and Neck Pathology | Ausgabe 1/2023

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Abstract

Background

Myoepithelial neoplasms of the salivary gland are benign or malignant neoplasms composed exclusively of neoplastic myoepithelial cells. These tumors, including the benign myoepithelioma and the malignant counterpart myoepithelial carcinoma, exhibit a wide range of cytomorphologic features and architectural patterns.

Methods

Review.

Results

Myoepithelial cells can be epithelial, plasmacytoid, clear cell, spindle cell, and/or oncocytic cell, arranging as trabeculae, solid sheets, nests, cords, and/or single cells. A stromal component is commonly but not universally present, Therefore, their differential diagnoses are quite broad, including salivary gland neoplasms especially those with a myoepithelial component, plasmacytoma, melanoma, and various mesenchymal tumors.

Conclusion

In this review, we summarize the characteristic histologic features, useful immunohistochemical panel, and common molecular alterations of myoepithelial tumors and their top differential diagnoses. A logical stepwise algorithmic approach and an immunohistochemical panel to include multiple myoepithelial markers are essential to establish the correct diagnosis.
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Metadaten
Titel
Top Ten Differentials to Mull Over for Head and Neck Myoepithelial Neoplasms
verfasst von
Lester D. R. Thompson
Bin Xu
Publikationsdatum
16.03.2023
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2023
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-022-01502-0

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